2012
DOI: 10.1111/j.1349-7006.2012.02211.x
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Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon‐inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation

Abstract: The development of oral squamous cell carcinoma (OSCC) is a multistep process that requires the accumulation of genetic alterations. To identify genes responsible for OSCC development, we performed high-density single nucleotide polymorphism array analysis and genome-wide gene expression profiling on OSCC tumors. These analyses indicated that the absent in melanoma 2 (AIM2) gene and the interferon-inducible gene 16 (IFI16) mapped to the hematopoietic interferon-inducible nuclear proteins. The 200-amino-acid re… Show more

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Cited by 61 publications
(69 citation statements)
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“…Furthermore, the restoration of AIM2 expression in p53-deficient OSCC cells increased cell proliferation and activated NF-jB activity. In contrast, the Absent in melanoma 2 proteins in the development of cancer restoration of AIM2 expression in OSCC cells that expressed the functional p53 inhibited cell growth [32]. Importantly, these observations raised an interesting possibility that AIM2-mediated inhibition of cell growth in OSCC cells and possibly other cell types depends on the p53 functions.…”
Section: Increased Expression Of Aim2 In Certain Virusassociated Andmentioning
confidence: 59%
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“…Furthermore, the restoration of AIM2 expression in p53-deficient OSCC cells increased cell proliferation and activated NF-jB activity. In contrast, the Absent in melanoma 2 proteins in the development of cancer restoration of AIM2 expression in OSCC cells that expressed the functional p53 inhibited cell growth [32]. Importantly, these observations raised an interesting possibility that AIM2-mediated inhibition of cell growth in OSCC cells and possibly other cell types depends on the p53 functions.…”
Section: Increased Expression Of Aim2 In Certain Virusassociated Andmentioning
confidence: 59%
“…The development of oral squamous cell carcinoma (OSCC) is associated with the amplification of the 1q23 region, and genes within this region, such as AIM2, are overexpressed [32]. Intriguingly, knockdown of AIM2 expression in OSCC cell lines resulted in decreased activation of NF-jB and suppression of cell growth and apoptosis [32].…”
Section: Increased Expression Of Aim2 In Certain Virusassociated Andmentioning
confidence: 99%
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“…Loss of IFI16 results in deregulation of p53-mediated apoptosis in breast cancer [8] . Consistently, overexpressed IFI16 has no effect on cell growth in p53-inactived oral squamous cell carcinoma [49] . Our previous hypothesis also proposed that IFI16 mis-localization may be a contributing factor to HCC progression [21] .…”
Section: Discussionmentioning
confidence: 63%
“…In support of the role of AIM2 inflammasome as a suppressor of cancer, it has been found that colorectal cancer patients, whose tissues showed a reduced AIM2 expression have a poorer prognosis compared to those with an up-regulation of AIM2 (Dihlmann et al, 2014). Moreover, AIM2 downregulation has also been reported in prostate cancer (Ponomareva et al, 2013), whereas increased expression has been detected in nasopharyngeal carcinoma Chen et al, 2012), oral squamous cell carcinoma (Kondo et al, 2012) and lung adenocarcinoma (Kong et al, 2015), suggesting that the differential expression of AIM2 in a range of tumor tissues could relate to its possible unique role in different types of cancer (Man et al, 2016). The mechanism by which AIM2 regulates tumorigenesis has been demonstrated by Wilson et al (2015) and described in a mouse model of colitis-associated colorectal cancer (Man et al, 2015b).…”
Section: The Duality Of Aim2: An Overviewmentioning
confidence: 96%