Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature

Kemp, Sanne R. Martens-de; Komor, Malgorzata A.; Hegi, Rosa; Bolijn, Anne S.; Tijssen, Marianne; Groen, Florence L. M. de; Depla, Annekatrien; Leerdam, Monique van; Meijer, Gerrit A.; Fijneman, Remond J.A.; Carvalho, Beatriz

doi:10.1016/j.neo.2022.100820

Cited by 7 publications

(2 citation statements)

References 63 publications

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“…This amplification is associated with CRC progression and plays a crucial role in the transition from colorectal adenoma to carcinoma. It is also implicated in the promotion of 13q chromosomal gain [ 27 ]. Additionally, during the transition from colorectal adenoma to adenocarcinoma, there is a notable increase in miR-17-92 cluster expression, which is linked to DNA copy number gains at the miR17-92 locus on chromosome 13q31 and heightened c-Myc expression.…”

Section: Mechanisms Underlying Altered Mir-17-92 Expression In Colore...mentioning

confidence: 99%

Unraveling the Multifaceted Role of the miR-17-92 Cluster in Colorectal Cancer: From Mechanisms to Biomarker Potential

Al-nakhle

2024

CIMB

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Colorectal cancer (CRC) is a complex disease driven by intricate mechanisms, making it challenging to understand and manage. The miR-17-92 cluster has gained significant attention in CRC research due to its diverse functions and crucial role in various aspects of the disease. This cluster, consisting of multiple individual miRNAs, influences critical processes like tumor initiation, angiogenesis, metastasis, and the epithelial–mesenchymal transition (EMT). Beyond its roles in tumorigenesis and progression, miR-17-92′s dysregulation in CRC has substantial implications for diagnosis, prognosis, and treatment, including chemotherapy responsiveness. It also shows promise as a diagnostic and prognostic biomarker, offering insights into treatment responses and disease progression. This review provides a comprehensive overview of recent advancements and the context-dependent role of the miR-17-92 cluster in colorectal cancer, drawing from the latest high-quality published data. It summarizes the established mechanisms governing miR-17-92 expression and the molecular pathways under its influence. Furthermore, it examines instances where it functions as an oncogene or a tumor suppressor, elucidating how cellular contexts dictate its biological effects. Ultimately, miR-17-92 holds promise as a biomarker for prognosis and therapy response, as well as a potential target for cancer prevention and therapeutic interventions. In essence, this review underscores the multifaceted nature of miR-17-92 in CRC research, offering promising avenues for enhancing the management of CRC patients.

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Section: Mechanisms Underlying Altered Mir-17-92 Expression In Colore...mentioning

confidence: 99%

Unraveling the Multifaceted Role of the miR-17-92 Cluster in Colorectal Cancer: From Mechanisms to Biomarker Potential

Al-nakhle

2024

CIMB

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“…Downregulation of TS-miR- The miR-17-92 cluster (miRs-17, -18a, -19a, -20a, -19b, and -92a) downregulates PTEN (phosphate and tensin homolog), E2F, the transforming growth factor-β (TGF-β) signaling pathway, B cell lymphoma/leukemia 2-like protein 11 (BCL2L11), and thrombospondin-1 (TSP-1) [8]. Functionally, it favors tumor growth and is reported to be overexpressed in small-cell lung cancer, colon cancer, hepatocellular carcinoma, thyroid cancer, colorectal adenoma organoids, and renal cell carcinoma [9][10][11][12][13][14].…”

Section: Role Of Mirnas In Cancermentioning

confidence: 99%

miRNAs: Potential as Biomarkers and Therapeutic Targets for Cancer

Chakrabortty

Patton

Smith

et al. 2023

Genes

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MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that regulate gene expression post-transcriptionally by binding to messenger RNAs. miRNAs are important regulators of gene expression, and their dysregulation is implicated in many human and canine diseases. Most cancers tested to date have been shown to express altered miRNA levels, which indicates their potential importance in the oncogenic process. Based on this evidence, numerous miRNAs have been suggested as potential cancer biomarkers for both diagnosis and prognosis. miRNA-based therapies have also been tested in different cancers and have provided measurable clinical benefits to patients. In addition, understanding miRNA biogenesis and regulatory mechanisms in cancer can provide important knowledge about resistance to chemotherapies, leading to more personalized cancer treatment. In this review, we comprehensively summarized the importance of miRNA in human and canine cancer research. We discussed the current state of development and potential for the miRNA as both a diagnostic marker and a therapeutic target.

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MicroRNA based combinatorial therapy against TKIs resistant CML by inactivating the PI3K/Akt/mTOR pathway: a review

Singh

2023

Med Oncol

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Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature

Cited by 7 publications

References 63 publications

Unraveling the Multifaceted Role of the miR-17-92 Cluster in Colorectal Cancer: From Mechanisms to Biomarker Potential

Unraveling the Multifaceted Role of the miR-17-92 Cluster in Colorectal Cancer: From Mechanisms to Biomarker Potential

miRNAs: Potential as Biomarkers and Therapeutic Targets for Cancer

MicroRNA based combinatorial therapy against TKIs resistant CML by inactivating the PI3K/Akt/mTOR pathway: a review

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