Overexpression of stathmin promotes metastasis and growth of malignant solid tumors: a systemic review and meta-analysis

Abstract

Stathmin has been investigated to be involved in development and progress of malignant tumors. This study was to clarify the relationship between expression of stathmin and tumors and assess its clinical significance. We identified 25 studies with a total of 3,571 individuals from the electronic bibliographic databases and strictly evaluated the quality and heterogeneity of included studies. We analysed the relationship between expression of stathmin and clinical characteristics by the fixed-effects and random-effects of meta-analysis and constructed a summary receiver-operator characteristic curve to estimate the test characteristics. The results showed that patients with cancer displayed a higher stathmin expression than those of non-cancer individuals (OR, 0.31), and overexpression of stathmin correlated with tumor cell differentiation (OR, 0.73), lymph node invasion (OR, 0.80) and high TNM stage (OR, 0.67). The pooled sensitivity of stathmin for distinguishing malignant tumors was 0.73 and the specificity was 0.77. The maximum balance joint for sensitivity and specificity (the Q-value) was 0.7566 and the area under the curve (AUC) was 0.8234. In conclusion, these results showed that overexpression of stathmin intimately correlated with malignant behavior of tumors, suggesting it could be a risk factor of malignant tumors. Stathmin had great sensitivity and specificity indicated it should be a significant molecular biomarker for malignant tumors.

Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies

“…Each study was judged on eight items, categorized into three groups: the selection of the study groups; the comparability of the groups; and the ascertainment of either the exposure or outcome of interest for case-control or cohort studies respectively. A qualified project was awarded a star and the highest quality research will be awarded 9 stars [9,10]. The two authors performed the evaluation independently.…”

Label‐Free Quantitative Phosphoproteomics Reveals Regulation of Vasodilator‐Stimulated Phosphoprotein upon Stathmin‐1 Silencing in a Pair of Isogenic Colorectal Cancer Cell Lines

“…[19] Recently, over-expression of STMN1 was found to correlate with malignant behavior of tumors, and STMN1 was purported as a molecular biomarker for diagnosis and target for therapy of malignant tumor. [12] In this work, we carried out quantitative phosphoproteomics analysis of STMN1 knockdown CRC cells. Global phosphoproteome analysis has been reported by using stable isotope labeling techniques, e.g.…”

“…[4][5][6][7][8] Recently, it has also been shown to be over-expressed and associated with metastasis, cancer progression, and poor prognosis in several human malignancies. [9][10][11][12][13][14][15][16][17] Similarly, we had reported earlier that STMN1 is a hallmark of CRC progression and predictor for poor survival, [18] and that STMN1 silencing resulted in arrest of tumordisseminative cascades. [19] Our proteome study of STMN1 knockdown cells showed that the protein expression and oncogenic signaling pathways are altered during metastatic transition in CRC, and the proteins that are regulated by STMN1 silencing function predominantly in metastatic processes and signaling.…”

A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ

“…It has been shown to be over-expressed in MM cell lines and tumour samples (45) and it is over expression is consistently associated with increased metastasis and malignant growth (46). Over-expression of miR-223 and siRNA knock-down in MM cell lines reduces stathmin expression, resulting in inhibition of motility and tubulin acetylation via a JNK signalling pathway-dependant mechanism (47).…”