Overexpression of splicing factor poly(rC)-binding protein 1 elicits cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells
Abstract:Background Splicing factor poly(rC)-binding protein 1 (PCBP1) is a novel tumor suppressor that is downregulated in many cancers thereby regulates tumor formation and metastasis. However, to date, little information has been available on the molecular mechanisms by which PCBP1 evokes apoptosis.Results Here, we explored the molecular mechanism by which PCBP1 triggers apoptosis in human cervical cancer cells. We testified that overexpression of PCBP1 greatly repressed proliferation of HeLa cells in time-dependen… Show more
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