Overexpression of ROMO1 and OMA1 are Potentially Biomarkers and Predict Unfavorable Prognosis in Gastric Cancer

Amini, Mohammad Amin; Karimi, Jamshid; Khodadadi, Iraj; Tavilani, Heidar; Talebi, Seyed Saman; Afshar, Behrouz

doi:10.1007/s12029-019-00330-w

Cited by 18 publications

(22 citation statements)

References 28 publications

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“…OMA1, as an ATP‐dependent zinc metalloprotease located in the mitochondrial inner membrane, was previously reported to be activated by self‐cleavage during stress conditions and participate in mitochondrial protein quality control (Käser et al , 2003; Baker et al , 2014; Zhang et al , 2014; Bohovych et al , 2016), and some recent research starts to link the OMA1 expression to gastric cancer initiation and breast cancer metastasis (Amini et al , 2019; Daverey et al , 2019). In our present study, the bioinformatics analyses showed the expression of OMA1 is upregulated in the tumors from colorectal cancer patients and increased OMA1 expression correlates with poor prognosis (Fig 1A and B).…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, recent studies revealed another piece of evidence that stress‐activated OMA1 mediates the cleavage of DELE1, which then relays mitochondrial stress to the cytosol (Fessler et al , 2020; Guo et al , 2020). So far, the role of OMA1 in cancer is complicated, depending on the type of cancer, the disease stage, the treatment, and many other factors (Jiang et al , 2014; Alavi, 2019; Amini et al , 2019; Daverey et al , 2019), and the underlying mechanism of OMA1 in regulating tumorigenesis and progression remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

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OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development

Zuo

Zeng

et al. 2020

EMBO Reports

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Many cancer cells maintain enhanced aerobic glycolysis due to irreversible defective mitochondrial oxidative phosphorylation (OXPHOS). This phenomenon, known as the Warburg effect, is recently challenged because most cancer cells maintain OXPHOS. However, how cancer cells coordinate glycolysis and OXPHOS remains largely unknown. Here, we demonstrate that OMA1, a stress-activated mitochondrial protease, promotes colorectal cancer development by driving metabolic reprogramming. OMA1 knockout suppresses colorectal cancer development in AOM/DSS and xenograft mice models of colorectal cancer. OMA1-OPA1 axis is activated by hypoxia, increasing mitochondrial ROS to stabilize HIF-1a, thereby promoting glycolysis in colorectal cancer cells. On the other hand, under hypoxia, OMA1 depletion promotes accumulation of NDUFB5, NDUFB6, NDUFA4, and COX4L1, supporting that OMA1 suppresses OXPHOS in colorectal cancer. Therefore, our findings support a role for OMA1 in coordination of glycolysis and OXPHOS to promote colorectal cancer development and highlight OMA1 as a potential target for colorectal cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development

Zuo

Zeng

et al. 2020

EMBO Reports

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“…Interestingly, ROC curve analysis suggested that ROMO1 could be considered as a potential tumor marker for bladder cancer. ROMO1 has shown to be a potential biomarker in cancer and anticipate unfavorable prognosis in cancer [27]. Finally, it can be concluded that this important mitochondrial protein can predispose individuals to develop bladder cancer, thereby increasing the level of free radical agents.…”

Section: Discussionmentioning

confidence: 97%

“…Recently, Amini and colleagues have found that increased expression of ROMO1 plays an essential role in the growth and development of gastric cancer [27]. Several lines of evidence demonstrated that increased expression of ROMO1 and oxidative stress are positively correlated to different pathologic conditions.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer

et al. 2020

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Reactive Oxygen Species Modulator 1 (ROMO1) plays a pivotal role in the regulation of mitochondrial structure integrity, and the production of reactive oxygen species (ROS). Increased ROMO1 expression was reported in various cancer cell lines; however, the possible association between ROMO1 expression and bladder cancer was not well studied. The present study aimed to investigate the rate of ROMO1 expression and the correlation of oxidative stress with the development of bladder cancer. In this study, a total of 35 cancerous and healthy adjacent tissues were examined using quantitative real-time polymerase chain reaction (qRT-PCR) to analyze the gene expression of ROMO1. Also, we evaluated the serum level of ROMO1 and Total Antioxidant Capacity (TAC), as well as Total Oxidant Status (TOS) in patients with bladder cancer along with age-and sex-matched healthy individuals. The ROMO1 gene was significantly higher in cancerous tissues than that of adjacent healthy tissues. Also, the serum levels of ROMO1, TAC, TOS, and Oxidative Stress Index (OSI) were increased in patients with bladder cancer compared with healthy subjects. It can be concluded that the overexpression of the ROMO1 gene is associated with advanced grades of bladder cancer as well as an increase in oxidative stress conditions. Our findings also suggest that the serum level of ROMO1 might be a promising tumor marker for bladder cancer.

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“…Most patients with gastric cancer are identi ed in advanced stages of the disease. Although speci c diagnostic and treatment methods for gastric cancer have been used, the survival rate of these patients is about 5 years, which is a very low survival rate [3][4][5][6][7]. Today, certain tumor markers are used such as CA19-9 and carcinoma embryonic antigen (CEA) to diagnose gastric cancer, but they have no speci city to diagnose this malignancy [8].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of TPT1-AS1 and SAMMSON and down expression of LINC00961 associated with Advanced Grades of Gastric Cancer

Amini

Karimi

Khodadadi

et al. 2020

Preprint

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Background One of the deadliest cancers in the world is gastric cancer. Long non-coding RNAs play prominent roles in cancer. LINC00961, TPT1-AS1, and SAMMSON have recently been discovered, which significantly contribute in various cancers and can affect the tumor size, grade of tumors and the metastasis condition. The aim of this study was to determine LINC00961, SAMMSON and TPT1-AS1 expression in gastric cancer tissues in comparison with healthy adjacent tissues. Methods The number of cancerous tissues and control groups was calculated to be at 40 (n = 40) and were analyzed by Quantitative real-time polymerase chain reaction. Results We found that overexpression of TPT1-AS1 and SAMMSON, and downexpression of LINC00961 in cancerous tissues in comparison with healthy adjacent tissues. A positive association between TPT1-AS1 and SAMMSON expression and tumor grade was observed. The level of mRNA folding change increased in cancer group compared to control group and *P < 0.05 is considered for mRNA folding change. Conclusion Finally, we found that overexpression of TPT1-AS1 and SAMMSON, and downexpression of LINC00961 were observed significantly in gastric cancer tissues in comparison with adjacent non-cancerous tissues. These lncRNAs were suggested as potential tumor markers for the diagnosis and treatment of gastric cancer.

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Overexpression of ROMO1 and OMA1 are Potentially Biomarkers and Predict Unfavorable Prognosis in Gastric Cancer

Cited by 18 publications

References 28 publications

OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development

OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development

Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer

Overexpression of TPT1-AS1 and SAMMSON and down expression of LINC00961 associated with Advanced Grades of Gastric Cancer

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