Overexpression of Rab27B is correlated with distant metastasis and poor prognosis in ovarian cancer

Abstract

Abstract. The secretory small guanosine-5'-triphosphate-binding enzyme, Rab27B, has been identified to be an oncogene that is involved in the progression of certain tumors. The current study was designed to evaluate the expression pattern of Rab27B in ovarian cancer (OC), borderline tumors and benign ovarian adenoid tumors, as well as its association with survival prognosis and clinical parameters. The expression of Rab27B protein was examined by immunohistochemistry in 204 patients who had undergone ovarian resection without preoperative systemic chemotherapy at the Surgical Department of the Affiliated Hospital of Nantong University (Nantong, China), including 57 benign ovarian adenoid tumors, 44 borderline tumors and 103 malignant tumors. Rab27B expression and clinicopathological features were analyzed with the χ 2 test. Patient survival rate was analyzed with the Kaplan-Meier method. Univariate and multivariate analysis of the prognostic factors was performed using the Cox regression model. Increased expression of Rab27B was positively correlated with histological type (P=0.012), level of differentiation (P=0.015), lymph node metastasis (P=0.024), distant metastasis (P<0.001) and International Federation of Gynecology and Obstetrics stage (P=0.001). Survival analysis revealed an association between Rab27B-positivity and poor overall survival rate. Multivariate analysis indicated that Rab27B (P<0.031) and distant metastases (P=0.031) were independent prognostic factors for OC patients' survival. The results of the present study supported the hypothesis that Rab27B may be a valuable prognostic indicator in patients with OC.

MicroRNA‑599 suppresses glioma progression by targeting RAB27B

“…YU JIANG 1* , XIAOHUI WANG 2* , JI ZHANG 3 (13). Deregulation of RAB27B has been observed in a number of common cancer types (14,15). For instance, RAB27B was determined to be significantly upregulated in ovarian cancer tissues, where it was associated with distant metastasis and poor prognosis (15).…”

Prognostic role of Rab27A and Rab27B expression in patients with non‐small cell lung carcinoma

“…Previous studies have found that high Rab27B expression is related to prognosis in patients with hepatocellular carcinoma, pancreatic ductal ADC, ovarian cancer, and gastrointestinal tumors; our findings are consistent with these results. 6,7,9,18 In addition, other studies have shown that Rab27A has a prognostic effect in several cancers, including hepatocellular carcinoma, colorectal cancer, glioma, and pancreatic ductal ADC. 7,13,14,16,19 However, we did not observe any relationship between Rab27A expression and prognosis in patients with NSCLC.…”

“…reported that Rab27A controls exosome secretion in lung adenocarcinoma (ADC) cells . Furthermore, some reports have demonstrated that Rab27A and Rab27B are associated with tumor progression and have been used as a prognostic factor in hepatocellular carcinoma; glioma; and pancreatic, ovarian, and colorectal cancers …”

“…4 Rab proteins belong to the Ras family of small GTPases and play a role in the activation of the GTP-binding enzymatic cycle, anchor to the vesicular membrane, and interact with effectors in the posttranscriptional process. 5,6 Rab27A and Rab27B are Rab proteins that are expressed in many types of secretory epithelial cells, although Rab27B is much more restricted than Rab27A. 7 More importantly, Rab27A and Rab27B are the major regulators of vesicle fusion and trafficking in the exosome secretion process.…”

“…12 Furthermore, some reports have demonstrated that Rab27A and Rab27B are associated with tumor progression and have been used as a prognostic factor in hepatocellular carcinoma; glioma; and pancreatic, ovarian, and colorectal cancers. 6,7,9,13,14 To our knowledge, no study has investigated the prognostic roles of Rab27A and Rab27B in NSCLC. Therefore, this study evaluated Rab27A and Rab27B expression, their correlation with clinicopathological data, and their prognostic significance in NSCLC.…”