Overexpression of p53 in squamous cell carcinoma of the tongue in young patients with no known risk factors is not associated with mutations in exons 5-9

Lingen, Mark W.; Chang, Kou Wei; McMurray, Scott J.; Solt, Dennis B.; Kies, Merrill S.; Mittal, Bharat B.; Haines, G. Kenneth; Pelzer, Harold J.

doi:10.1002/1097-0347(200007)22:4<328::aid-hed3>3.0.co;2-r

Cited by 71 publications

(62 citation statements)

References 57 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The primary risk factors for OSCC are tobacco and alcohol use. While some studies report that young patients parallel the OSCC population in general by displaying a high proportion of cases with a history of significant tobacco and alcohol use, others suggest that young patients usually lack such a history [3,13,[17][18][19]. In addition, exposure to these risk factors must be of long enough duration to have a detrimental effect.…”

Section: Discussionmentioning

confidence: 99%

“…This points to the potential influence of additional etiologic factors-such as genetic susceptibility, immunodeficiency, or viral infection-may be at work [2,3,12,21,22]. Lingen et al studied the overexpression of p53 in individuals \40 years old with tongue cancer and no known risk factors [17]. They noted that 81% of these patients overexpressed p53 protein but did not exhibit mutations in exons 5-9 of the p53 gene, which are known to exist in at least 50% of OSCC in older patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Changing Trends in Oral Squamous Cell Carcinoma with Particular Reference to Young Patients: 1971–2006. The Emory University Experience

Müller

Pan

et al. 2008

Head and Neck Pathol

View full text Add to dashboard Cite

Background Several recent reports suggest an increasing incidence of oral squamous cell carcinoma (OSCC) among young persons in many regions of the world-a trend which is particularly concerning given the overall stabilization or even decline in incidence rates for head and neck cancer in general. The aim of this study is to determine whether there has been an increase in the number of cases of OSCC diagnosed in patients \40 years old by our biopsy service from 1971 to 2006. Methods A retrospective review of all OSCC cases diagnosed from 1971 to 2006 by the Emory University Hospital Oral Pathology biopsy service was performed. A comparison of demographic information, frequency, location and histologic grade was made between these cases as a whole and those occurring in a subset of patients \40 years old. Statistical procedures included chi-square analyses. Results From 1971-2006, 1,919 cases of OSCC were diagnosed, and 95 (5.0%) occurred in patients \40 years old.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Changing Trends in Oral Squamous Cell Carcinoma with Particular Reference to Young Patients: 1971–2006. The Emory University Experience

Müller

Pan

et al. 2008

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…1 Anualmente são diagnosticados 50.000 casos de CCE da cabeça e pescoço nos EUA e mais de 500.000 no mundo. 2 No Brasil as estimativas das taxas de incidência do câncer oral relatadas pelo INCA para o ano de 2002 são de 8.340 casos para homens e 2.915 para as mulheres, com 2.715 óbitos para os homens e 700 óbitos para as mulheres. 3 No estado do Rio de Janeiro são estimados 1.410 casos de câncer oral para homens e 530 casos para as mulheres, sendo 420 óbitos para homens e 100 óbitos para as mulheres.…”

Section: Introductionunclassified

“…3 A literatura científica tem recentemente dado mais atenção aos CCE ocorridos na língua de adultos jovens, o que não era considerado uma entidade clínica distinta dos carcinomas de células escamosas em adultos até 1975 2,4-12 , pois os CCE de cabeça e pescoço em adultos jovens são incomuns, representando apenas de 0,4% a 4,8% de todos estes tumores ocorridos em pacientes com mais de 40 anos. 2 Uma revisão da literatura americana revela menos de 200 casos reportados de CCE de língua em pacientes com menos de 40 anos. 2 Logo, existem muito poucas publicações sobre o tratamento e o efeito desta doença, devido a sua raridade.…”

Section: Introductionunclassified

“…2 Uma revisão da literatura americana revela menos de 200 casos reportados de CCE de língua em pacientes com menos de 40 anos. 2 Logo, existem muito poucas publicações sobre o tratamento e o efeito desta doença, devido a sua raridade. 5 Tem sido sugerido que o CCE oral em pacientes jovens talvez seja uma doença distinta daquela que ocorre em pacientes mais velhos, com etiologia e progressão clínica particulares.…”

Section: Introductionunclassified

See 1 more Smart Citation

Carcinoma de células escamosas da cavidade oral em pacientes jovens e sua crescente incidência: revisão de literatura

Venturi¹,

Pamplona

Cardoso

2004

Rev. Bras. Otorrinolaringol.

View full text Add to dashboard Cite

A proposta deste estudo é rever o carcinoma de células escamosas oral na população jovem. A literatura mostra um comportamento diferente neste tipo de doença, que parece ser mais agressivo. Existe uma forte relação entre alguns hábitos (tabaco e consumo de álcool) e o desenvolvimento do carcinoma de células escamosas (CCE) oral, mas nestes casos os pacientes normalmente não relatam hábitos considerados de risco. Existe um pequeno número de relatos de casos de CCE oral em pacientes com menos de 40 anos de idade, então é difícil de provar o aumento da incidência do CCE da cavidade oral como dito na literatura. Outros estudos são necessários para entendermos melhor esta entidade. A identificação das características desta população jovem se faz necessária, pois pode refletir problemas no controle do câncer e pode possibilitar o desenvolvimento de um programa de prevenção primária para o CCE oral em pacientes jovens.

show abstract

Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma

Rusthoven

Ballonoff

Raben

et al. 2007

Cancer

163

130

View full text Add to dashboard Cite

Coarse grain (CG) molecular models have been proposed to simulate complex systems with lower computational overheads and longer timescales with respect to atomistic level models. However, their acceleration on parallel architectures such as graphic processing units (GPUs) presents original challenges that must be carefully evaluated. The objective of this work is to characterize the impact of CG model features on parallel simulation performance. To achieve this, we implemented a GPU‐accelerated version of a CG molecular dynamics simulator, to which we applied specific optimizations for CG models, such as dedicated data structures to handle different bead type interactions, obtaining a maximum speed‐up of $14$ on the NVIDIA GTX480 GPU with Fermi architecture. We provide a complete characterization and evaluation of algorithmic and simulated system features of CG models impacting the achievable speed‐up and accuracy of results, using three different GPU architectures as case studies. © 2012 Wiley Periodicals, Inc.

show abstract

Overexpression of p53 in squamous cell carcinoma of the tongue in young patients with no known risk factors is not associated with mutations in exons 5-9

Cited by 71 publications

References 57 publications

Changing Trends in Oral Squamous Cell Carcinoma with Particular Reference to Young Patients: 1971–2006. The Emory University Experience

Changing Trends in Oral Squamous Cell Carcinoma with Particular Reference to Young Patients: 1971–2006. The Emory University Experience

Carcinoma de células escamosas da cavidade oral em pacientes jovens e sua crescente incidência: revisão de literatura

Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma

Contact Info

Product

Resources

About