“…In this context, loss of heterozygosity (LOH) at the p300 locus has been observed in numerous cancers, including hepatocellular, colorectal, oral, breast, ovarian, gastric carcinomas and glioblastomas [11]. Consistently, several studies have also shown that loss of p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma (HCC) [12, 13], breast cancer [14], cutaneous squamous cell carcinoma (SCC) [15] and nasopharyngeal carcinoma [16]. However, p300 is also found to be overexpressed in prostate cancer, where it regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth [5, 17, 18].…”