Overexpression of p27Kip1 induces growth arrest and apoptosis in an oral cancer cell line

Supriatno, .; Harada, Koji; Hoque, Mohammad O.; Bando, Takashi; Yoshida, Hideo; Sato, Mitsunobu

doi:10.1016/s1368-8375(02)00011-8

Cited by 37 publications

(27 citation statements)

References 21 publications

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“…B88 cells were isolated from a cervical lymph node metastasis of an oral tongue squamous cell carcinoma patient (22). The primary tumor of B88 cells was moderately differentiated squamous cell carcinoma of the tongue, and was not invasive into the muscle layer.…”

Section: Methodsmentioning

confidence: 99%

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Effect of intratumoral injection of mutant type p27Kip1 followed by in vivo electroporation on radiotherapy-resistant human oral tongue cancer xenografts

Supriatno

Yuletnawati²,

Widiasto

2010

Mol Med Rep

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Section: Methodsmentioning

confidence: 99%

“…Kip1 gene also leads to inhibition of proliferation, invasion and metastasis (21,22). a low level of p27…”

Section: Introductionmentioning

confidence: 99%

Effect of intratumoral injection of mutant type p27Kip1 followed by in vivo electroporation on radiotherapy-resistant human oral tongue cancer xenografts

Supriatno

Yuletnawati²,

Widiasto

2010

Mol Med Rep

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“…B88 cells were isolated from a patient with OSCC in our laboratory (24). HSC3 cells (OSCC) were obtained from American Type Culture Collection (Manassas, VA, USA).…”

Section: Methodsmentioning

confidence: 99%

Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8

Harada$^{¹

2009

Int J Oncol

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Abstract. Cepharanthine is a biscoclaurine alkaloid extracted from Stephania cepharantha Hayata, which is widely used for the treatment of many acute and chronic diseases, and can exert antitumor effects on several human cancer cell lines. However, little is known about the detailed mechanisms of the antitumor activity of Cepharanthine. In the present study, we determined whether Cepharanthine could suppress angiogenesis and growth of human oral squamous cell carcinoma (OSCC) cells in vitro and in vivo. Cepharanthine significantly inhibited expression of two major pro-angiogenic molecules, vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), in cultured cells and in cells implanted into the subcutaneous tissue of nude mice. Also, Cepharanthine inhibited the nuclear factor-κB (NF-κB) activity in human OSCC cells in vitro and in vivo. The decreased expression of VEGF and IL-8 correlated with decreased tumor cell growth and decreased vascularization in vitro and in vivo. These findings suggest that Cepharanthine can suppress angiogenesis and growth of OSCC cells by inhibiting expression of VEGF and IL-8 involved in the blockade of NF-κB activity.

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“…22 The original tumor of SP-C1 cells was moderately differentiated squamous cell carcinoma of tongue, and was not invasive into muscle layer. Cells were maintained in Dulbecco's modified eagle medium (DMEM, Sigma, St Louis, MO, USA) supplemented with 10% fetal calf serum (FCS, Moregate BioTech, Bulimba, Australia), 100 g/ml streptomycin, and 100 units/ml penicillin (Invitrogen Corp., Carlsbad, CA, USA).…”

Section: Cell and Cell Culturementioning

confidence: 99%

Electro-gene therapy in a human oral tongue cancer cell by intratumoral injection of pcDNA3.1-p27<sup>Kip1</sup> wt

Supriatno

2007

Dent. J. (Majalah Kedokteran Gigi)

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Overexpression of p27Kip1 induces growth arrest and apoptosis in an oral cancer cell line

Cited by 37 publications

References 21 publications

Effect of intratumoral injection of mutant type p27Kip1 followed by in vivo electroporation on radiotherapy-resistant human oral tongue cancer xenografts

Effect of intratumoral injection of mutant type p27Kip1 followed by in vivo electroporation on radiotherapy-resistant human oral tongue cancer xenografts

Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8

Electro-gene therapy in a human oral tongue cancer cell by intratumoral injection of pcDNA3.1-p27<sup>Kip1</sup> wt

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