Overexpression of NLRP12 enhances macrophage immune response and alleviates herpes simplex keratitis
Jiaxuan Jiang,
Di Zhang,
Wei Liu
et al.
Abstract:IntroductionHerpes simplex keratitis (HSK) is a blinding disease caused by corneal infection of Herpes simplex virus type 1 (HSV-1). Effective clearance of HSV-1 from the infected cornea is crucial for HSK management. Macrophages play an important part in the innate immune defense against viral infections. This study investigates the immunomodulatory role of NLRP12 in macrophage immune response during HSV-1 infection.MethodsNLRP12 expression post-infection was assessed in various macrophage cell lines. Overexp… Show more
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