“…p75 NTR can bind all of the neurotrophins, but when compared to the Trks, striking differences in structure and intracellular signal transduction have been discovered (Charalampopoulos et al, 2012). Different deletion mutants of p75 NTR exhibit complex sensory and sympathetic abnormalities that vary depending on the precise mutation (Davies, Lee, & Jaenisch, 1993; Dhanoa, Krol, Jahed, Crutcher, & Kawaja, 2006; Lee et al, 1992; Majdan, Walsh, Aloyz, & Miller, 2001; Petrie et al, 2013; von Schack et al, 2001). Conditional NCC-specific p75 NTR mutants show effects consistent with a disruption in PNS development (Bogenmann et al, 2011).…”