Overexpression of NCAPG in ovarian cancer is associated with ovarian cancer proliferation and apoptosis via p38 MAPK signaling pathway

Yu, Haiting; Zou, Dan; Ni, N.; Zhang, Suxian; Zhang, Qin; Yang, Lihua

doi:10.21203/rs.3.rs-688105/v1

Cited by 2 publications

(3 citation statements)

References 25 publications

(23 reference statements)

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“…NCAPG (non-SMC condensin I complex, subunit G) is a mitose-associated chromosome condensation protein (32). Related studies have shown that NCAPG is signi cantly overexpressed in various tumors, including colorectal cancer, hepatocellular carcinoma, lung cancer, etc., and affects the biological functions of tumor cells such as proliferation, migration, invasion and apoptosis (33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

Lawsone inhibits the proliferation and metastasis of residual breast cancer cells after microwave ablation by inducing cellular inhibitory autophagy through NCAPG/AURKB/AKT/mTOR axis

Sun

Tong

Zhang

et al. 2023

Preprint

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Microwave ablation (MWA) is increasingly used in clinical treatment and research of breast cancer, which has good therapeutic effect on primary and metastatic lesions. However, microwave ablation may lead to residual tumor cells due to incomplete ablation. The biological characteristics of residual tumor cells are unknown, and it is necessary to explore new adjuvant treatment methods to achieve better therapeutic effect. In this study, we demonstrated that the migration ability of residual breast cancer cells was enhanced after microwave ablation, but the proliferation ability was not significantly changed. Lawsone, an active ingredient in Chinese herbal medicine, significantly inhibited the proliferation and metastasis of residual breast cancer cells after microwave ablation in vivo and in vitro, and had synergistic effects with microwave ablation therapy. Mechanistic studies have shown that Lawsone exerts its anti-proliferation and anti-migration ability mainly by targeting NCAPG in residual breast cancer after microwave ablation. In addition, Lawsone-induced cellular inhibitory autophagy also plays a key role in its anticancer effect. In addition, NCAPG interacts with AURKB protein and jointly participates in the regulation of AKT/mTOR pathway to affect autophagy process. In short, these consequences demonstrate that Lawsone exerts its anti-proliferation and anti-metastasis effects on residual breast cancer cells after microwave ablation mainly by inhibiting NCAPG/AURKB/AKT/mTOR axis and inducing inhibitory autophagy, which provides more options for adjuvant therapy after microwave ablation.

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Section: Discussionmentioning

confidence: 99%

Lawsone inhibits the proliferation and metastasis of residual breast cancer cells after microwave ablation by inducing cellular inhibitory autophagy through NCAPG/AURKB/AKT/mTOR axis

Sun

Tong

Zhang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…For example, microRNA (miR)-566 directly targets PSKH1, regulating colon cancer cell proliferation, migration and invasion (12). Various factors contribute to the development of tumors via the p38/MAPK signaling pathway (13,14). For example, downregulation of Non-SMC condensin I complex subunit G (NCAPG) could suppress OC cell proliferation and invasion via activating the p38 MAPK signaling pathway (13).…”

Section: Introductionmentioning

confidence: 99%

“…Various factors contribute to the development of tumors via the p38/MAPK signaling pathway (13,14). For example, downregulation of Non-SMC condensin I complex subunit G (NCAPG) could suppress OC cell proliferation and invasion via activating the p38 MAPK signaling pathway (13). The p38 pathway serves a crucial role in facilitating muscle differentiation, which confers its anti-tumor properties (15).…”

Section: Introductionmentioning

confidence: 99%

PSKH1 affects proliferation and invasion of osteosarcoma cells via the p38/MAPK signaling pathway

et al. 2023

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Malignant osteosarcoma (OS) is a tumor of bone and soft tissue that metastasizes early and has a high mortality rate. Protein serine kinase H1 (PSKH1), an autophosphorylating human protein serine kinase, controls the trafficking of serine/arginine-rich domain, with downstream effects on mRNA processing. It is also associated with tumor progression. However, how this protein contributes to OS progression and metastasis is unknown. The present study evaluated the potential effect of PSKH1 on proliferation of human OS cells. OS cell lines were used in Cell Counting Kit-8, colony formation, wound-healing and Transwell assays, to investigate cellular processes such as proliferation, migration and invasion and underlying molecular mechanisms. Expression of PSKH1 in OS tissue was significantly greater than in adjacent non-malignant tissue. PSKH1 knockdown inhibited the proliferation, migration and invasion of OS cells. Conversely, PSKH1 overexpression promoted proliferation of OS cells. PSKH1 upregulated phosphorylated-p38 in OS cells. Moreover, the p38 MAPK inhibitor SB203580 effectively blocked the tumor-promoting action of PSKH1. Furthermore, PSKH1 knockdown inhibited tumor growth and metastasis in vivo. In conclusion, these findings suggested that PSKH1 promoted OS proliferation, migration and invasion. Thus, PSKH1 may serve an oncogenic role in the development of human OS.

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Overexpression of NCAPG in ovarian cancer is associated with ovarian cancer proliferation and apoptosis via p38 MAPK signaling pathway

Cited by 2 publications

References 25 publications

Lawsone inhibits the proliferation and metastasis of residual breast cancer cells after microwave ablation by inducing cellular inhibitory autophagy through NCAPG/AURKB/AKT/mTOR axis

Lawsone inhibits the proliferation and metastasis of residual breast cancer cells after microwave ablation by inducing cellular inhibitory autophagy through NCAPG/AURKB/AKT/mTOR axis

PSKH1 affects proliferation and invasion of osteosarcoma cells via the p38/MAPK signaling pathway

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