Overexpression of MyoD Attenuates Denervated Rat Skeletal Muscle Atrophy and Dysfunction

Abstract

<span>Nerve injury commonly contributes to irreversible functional impairment, reconstruction of the function of muscle is big challenge. In denervated skeletal muscle, therapid expression of MyoD mRNA and protein also occurs during early postdenervation, which suggested that the function of denervation-induced MyoD may be to prevent denervation-induced skeletal muscle atrophy. However, the detail mechanism is not clear. Therefore, in this study, we established a stable-transfected MyoD L6 cell line. After the operation for cutting the rats’ tibial nerve, the MyoD-L6 cells were injected in the gastrocnemius, the function of the gastronemius was monitored. It was found that injected the MyoD-L6 cells could attenuate the muscle atrophy and dysfunction. Therefore, overexpression of MyoD could serve as a new therapy strategy to cure denervation-induced dysfunction of skeletal muscle.</span><span></span&gt

Ficus carica L. Attenuates Denervated Skeletal Muscle Atrophy via PPARα/NF-κB Pathway

“…A long period of denervation in patients with peripheral nerve injury or disease can lead to skeletal muscle atrophy ( Xiong et al, 2012 ; Ehmsen and Höke, 2020 ). However, the mechanisms underlying denervated muscle atrophy are not fully understood.…”

Modulation of satellite cells activity and MyoD in rat thyroarytenoid muscle after reinnervation

“…MyoD expressed in myofibers may prevent muscle atrophy because MyoD overexpression inhibited starvation‐induced atrophy of both mouse primary myotubes in vitro and skeletal muscle fibers in vivo . Furthermore, such overexpression reduced denervation‐induced atrophy of rat skeletal muscle . However, it remains clear that denervation induces skeletal muscle atrophy.…”