Overexpression of Midkine in malignant peripheral nerve sheath tumor cells inhibits apoptosis and increases angiogenic potency

Friedrich, Carsten; Holtkamp, Nikola; Činátl, Jindřich; Sakuma, Sadatoshi; Mautner, Victor; Wellman, Sven; Michaelis, M.; Henze, Günter; Kurtz, Andreas; Driever, Pablo Hernáiz

doi:10.3892/ijo.27.5.1433

Cited by 17 publications

(15 citation statements)

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“…24,59 Therefore, we suggest that the MK-Notch2-Stat3 pathway contributes to EMT, which is one of the important component of neonatal and tumor development. [5][6][7][8][9][10]31,[37][38][39][40][60][61][62][63] Since EMT plays a specific role in the migration of cells from a primary tumor into the circulation [1][2][3][4] an improved understanding of the role of MK-Notch2-Stat3 signaling in the EMT may provide a rationale for developing additional targeted cancer therapies. incubated with yeast extracts (100 μg) expressing the pGal4-ADNotch2 fusions tagged with HA-epitope.…”

Section: Discussionmentioning

confidence: 99%

Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes

Huang¹,

Hoque²,

Wu³

et al. 2008

Cell Cycle

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Epithelial-to-mesenchymal transition (EMT) underlies cell plasticity and embryonic development and is frequently observed in advanced tumorigenesis. We demonstrated that midkine (MK), a retinoic acid-inducible heparin-binding mitogen, promotes EMT in immortalized HaCaT keratinocytes. We showed that MK binds to the Notch2 receptor in HaCaT keratinocytes. We further found that MK activates Notch2 signaling leading to protein/protein interactions between Hes1 and Jak2/Stat3 intermediates. We thus suggest that MK-induced cross talk of Notch2/Jak2/Stat3 signaling pathways can regulate cell plasticity and motility contributing to the EMT and later stages of tumorigenesis.

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Section: Discussionmentioning

confidence: 99%

Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes

Huang¹,

Hoque²,

Wu³

et al. 2008

Cell Cycle

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show abstract

“…MK has mitogenic activity, anti-apoptotic activity, and angiogenic activity. MK is also involved in oncogenic transformation (44)(45)(46)(47)(48)(49). Many human malignant tumors express high levels of MK protein while normal human tissues including liver do not (50).…”

Section: Cancer-specific Promoter Systemsmentioning

confidence: 99%

Adenovirus-mediated cancer gene therapy and virotherapy (Review)

Fukazawa¹

2009

Int J Mol Med

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Abstract. Gene therapy and virotherapy are among the approaches currently used to treat malignant tumors. Gene therapy and virotherapy use a specific therapeutic gene that causes death in cancer cells. In early attempts at gene therapy, therapeutic genes were driven by ubiquitous promoters such as the CMV promoter, which induce non-specific toxicity to normal cells and tissues in addition to the cancer cells. Recently, novel cancer-and/or tissue-specific promoter systems have been developed to target cancer cells but not normal cells including stem cells. In this review, we describe cancer and/or tissue-specific gene therapy systems for the treatment of cancer. In particular, we will discuss three systems for gene therapy and virotherapy: i) tissue-specific promoter systems, ii) cancer-specific promoter systems, and iii) oncolytic virotherapy. We will also discuss the major challenges of cancer-targeting vector systems and future directions in this area.

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“…In adults, no expression is found, except in the kidney and intestinal epithelium. Previous studies have shown that MK is highly and frequently expressed in a variety of cancer tissues, demonstrating that MK may be associated with tumorigenesis and tumor growth, invasion and metastasis (14)(15)(16)(17)(18). MK binds to complex membrane protein receptors, including protein tyrosine phosphatase ζ (PTPζ), low-density lipoprotein-related protein (LRP), anaplastic lymphoma kinase and syndecan (19,20).…”

Section: Discussionmentioning

confidence: 99%

Overexpression of Midkine in malignant peripheral nerve sheath tumor cells inhibits apoptosis and increases angiogenic potency

Cited by 17 publications

References 0 publications

Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes

Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes

Adenovirus-mediated cancer gene therapy and virotherapy (Review)

Expression of midkine and vascular endothelial growth factor in gastric cancer and the association of high levels with poor prognosis and survival

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