Overexpression of Microrna-1 Controls the Development of Osteoarthritis via Targeting FZD7 of WNT/β-catenin Signaling

Xing, Dan; Wang, B.; Ke, Yan; Lin, Jianhua

doi:10.1016/j.joca.2017.02.535

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MicroRNAs (miRNAs) are commonly used to identify novel OA genes and their related inflammatory network [4]. A previous study shows that the upregulation of miR-1 controls the development of OA via targeting FZD7 of Wnt/β-catenin signaling [5]. Zhang et al indicated that miR-320 might target matrix metalloproteinase-13 and further affected the process of OA [6].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway

Liu

Gao

et al. 2020

J Orthop Surg Res

View full text Add to dashboard Cite

Background: This study aimed to explore the molecular mechanism of osteoarthritis (OA) and provide information about new genes as potential targets for OA treatment. Methods: Gene expression profile of GSE105027, including 12 OA serum samples (OA group) and 12 healthy serum samples (ctrl group), was downloaded. The differentially expressed miRNAs (DEMs) as well as miRNA-mRNAs interactions were investigated, followed by function and pathway investigation. Then the protein-protein interaction (PPI) network was performed. Furthermore, the long non-coding RNA (lncRNA)-miRNA-mRNA interactions (competing endogenous RNAs, ceRNAs) were investigated. Results: A total of 17 downregulated miRNAs were revealed between OA and ctrl groups. These DEMs such as has-miR-1202 were mainly enriched in GO functions like histone acetyltransferase binding and KEGG pathways like cellular senescence. The integrated PPI network analysis showed that has-miR-1202, has-miR-33b-3p, has-miR-940, has-miR-4284, and has-miR-4281 were 5 downregulated miRNAs in this network. Furthermore, the lncRNA-miRNA-mRNA interactions such as KCNQ1OT1-has-miR-1202-ETS1 were revealed in the present ceRNA network. Conclusion: Key DEMs such as miR-33b-3p, miR-940, and miR-1202 may be involved in OA. miR-1202 may regulate OA development via histone acetyltransferase pathway binding function and cellular senescence pathway. Furthermore, KCNQ1OT1-has-miR-1202-ETS1 might be vital for the process of OA.

show abstract

Section: Introductionmentioning

confidence: 99%

MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway

Liu

Gao

et al. 2020

J Orthop Surg Res

View full text Add to dashboard Cite

show abstract

“…All of the targets belonged to positive regulators of the Wnt pathway, and targeting them seemed to modulate the Wnt signaling negatively. In another line of research, miR-1 was demonstrated to inhibit chondrocyte degradation through FZD7 [46].…”

Section: Targeting Wnt Ligands/receptors and Associated Proteinsmentioning

confidence: 97%

The Interaction between microRNAs and the Wnt/β-Catenin Signaling Pathway in Osteoarthritis

Shang

Böker

Taheri

et al. 2021

IJMS

View full text Add to dashboard Cite

Osteoarthritis (OA) is a chronic disease affecting the whole joint, which still lacks a disease-modifying treatment. This suggests an incomplete understanding of underlying molecular mechanisms. The Wnt/β-catenin pathway is involved in different pathophysiological processes of OA. Interestingly, both excessive stimulation and suppression of this pathway can contribute to the pathogenesis of OA. microRNAs have been shown to regulate different cellular processes in different diseases, including the metabolic activity of chondrocytes and osteocytes. To bridge these findings, here we attempt to give a conclusive overview of microRNA regulation of the Wnt/β-catenin pathway in bone and cartilage, which may provide insights to advance the development of miRNA-based therapeutics for OA treatment.

show abstract

Overexpression of Microrna-1 Controls the Development of Osteoarthritis via Targeting FZD7 of WNT/β-catenin Signaling

Cited by 2 publications

References 0 publications

MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway

MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway

The Interaction between microRNAs and the Wnt/β-Catenin Signaling Pathway in Osteoarthritis

Contact Info

Product

Resources

About