Overexpression of KIAA0101 Predicts High Stage, Early Tumor Recurrence, and Poor Prognosis of Hepatocellular Carcinoma

Yuan, Ray-Hwang; Jeng, Yung‐Ming; Pan, Hung‐Wei; Hu, Fu‐Chang; Lai, Po-Lin; Lee, Po‐Huang; Hsu, Hey‐Chi

doi:10.1158/1078-0432.ccr-07-1113

Cited by 74 publications

(111 citation statements)

References 43 publications

Supporting

Mentioning

102

Contrasting

Order By: Relevance

“…KIAA0101 overexpression was associated with concomitant p53 mutation and vascular invasion (Yuan et al, 2007). This study suggested that high expression in hepatocellular carcinoma was indicative of tumour recurrence, metastatic potential and poor prognosis (Yuan et al, 2007).…”

Section: Hepatocellular Carcinomamentioning

confidence: 76%

“…Not detected in heart or liver (Yu et al, 2001). The KIAA0101 protein was down-regulated in human hepatocellular carcinoma (Guo et al, 2006;Yuan et al, 2007). Increased protein levels have been detected in pancreatic cancer cells (Hosokawa et al, 2007).…”

Section: Expressionmentioning

confidence: 97%

“…PCNA is required for DNA replication or repair as a supplementary factor for DNA polymerase (Paunesku et al, 2001). Proteins bound to PCNA can prevent its binding to DNA polymerase, in turn leading to inhibition of DNA synthesis, cell cycle progression and G1 cell cycle arrest (Yuan et al, 2007). PCNA binding proteins also interact with each other to modulate this regulation.…”

Section: Functionmentioning

confidence: 99%

“…Disease KIAA0101 expression was proposed to promote growth advantage and hypoxic insult resistance and be associated with promoting cell proliferation (Yuan et al, 2007). KIAA0101 overexpression was associated with concomitant p53 mutation and vascular invasion (Yuan et al, 2007).…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

See 3 more Smart Citations

Kiaa0101 (Kiaa0101)

Joseph¹,

Hu²,

Simpson³

2012

Atlas of Genetics and Cytogenetics in Oncology and Haematology

View full text Add to dashboard Cite

Section: Hepatocellular Carcinomamentioning

confidence: 76%

Section: Expressionmentioning

confidence: 97%

Section: Functionmentioning

confidence: 99%

Section: Hepatocellular Carcinomamentioning

confidence: 99%

See 2 more Smart Citations

Kiaa0101 (Kiaa0101)

Joseph¹,

Hu²,

Simpson³

2012

Atlas of Genetics and Cytogenetics in Oncology and Haematology

View full text Add to dashboard Cite

“…The protein product of the KIAA0101/p15 PAF gene is a protein implicated in proliferation and proliferating cell nuclear antigen (PCNA)-mediated DNA repair, all the while displaying oncogenic activity when aberrantly expressed, possibly through the same aforementioned pathway (89). Overexpression of KIAA0101 has been linked to growth and invasiveness of adrenal cancer (38), a predictor of poor survival in primary lung cancer (86), breast cancer (35), hepatocellular carcinoma (106), and gastric cancer (111). Although no published studies exist on KIAA0101 expression in MPM to date, based on the above it is likely that its previously mentioned PCNA-mediated oncogenic properties may play a major part.…”

Section: Functional Enrichment Annotation Analysis Of Gene Ontologiesmentioning

confidence: 99%

Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma

Vavougios

Solenov

Hatzoglou

et al. 2015

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

show abstract

Nodal yield and survival in oral squamous cancer

Ebrahimi

Zhang

Gao

et al. 2011

Cancer

136

160

View full text Add to dashboard Cite

BACKGROUND: Elective neck dissection (END) is commonly used as a staging and therapeutic procedure for oral squamous cell carcinoma (SCC) at high risk of nodal metastases. The authors aimed to determine whether the extent of lymphadenectomy, as defined by nodal yield, is a prognostic factor in this setting. METHODS: A retrospective database review identified 225 patients undergoing END with curative intent for oral SCC between 1987 and 2009. Nodal yield was studied as a categorical variable for association with overall, disease-specific, and disease-free survival in univariate and multivariate analyses. RESULTS: Nodal yield <18 was associated with 5-year overall survival of 51% compared with 74% in those with nodal yield 18 (P ¼ .009). Five-year disease-specific survival rates were 69% in those with <18 nodes and 87% in patients with 18 nodes (P ¼ .022). Similar results were obtained for disease-free survival, with 5-year rates of 44% with <18 nodes versus 71% with 18 nodes (P ¼ .043). After adjusting for the effect of age, nodal status, T stage, and adjuvant radiotherapy on multivariate analysis, nodal yield <18 was associated with reduced overall (hazard ratio [HR], 2.0; 95% confidence interval [CI], 1.1-3.6; P ¼ .020), disease-specific (HR, 2.2; 95% CI, 1.1-4.5; P ¼ .043), and disease-free survival (HR, 1.7; 95% CI, 1.1-2.8; P ¼ .040). In the pathologically lymph nodenegative subgroup (n ¼ 148), similar results were obtained. CONCLUSIONS: Nodal yield is an independent prognostic factor in patients undergoing END for oral SCC. These results suggest that an adequate lymphadenectomy in this setting should include at least 18 nodes.

show abstract

Overexpression of KIAA0101 Predicts High Stage, Early Tumor Recurrence, and Poor Prognosis of Hepatocellular Carcinoma

Abstract: KIAA0101 correlates with enhanced metastatic potential and is a significant prognostic factor of HCC.

Cited by 74 publications

References 43 publications

Kiaa0101 (Kiaa0101)

Kiaa0101 (Kiaa0101)

Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma

Nodal yield and survival in oral squamous cancer

Contact Info

Product

Resources

About