Overexpression of JAZF1 protected ApoE-deficient mice from atherosclerosis by inhibiting hepatic cholesterol synthesis via CREB-dependent mechanisms

Li, Xiaoqiang; Yang, Mengliu; Wang, Han; Jia, Yanjun; Yan, Pingping; Boden, Guenther; Yang, Gangyi; Li, Ling

doi:10.1016/j.ijcard.2014.09.007

Cited by 28 publications

(41 citation statements)

References 32 publications

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“…One week before the pancreatic‐euglycemic clamp (PEC), NCD or HFD‐fed rats from littermates housed in individual cages were randomly assigned into two groups to receive an MBH injection with either Ad‐ JAZF1 , Ad‐ GFP (5 μL, 1 × 10 9 pfu/mL) or aCSF. Seven days' post‐adenoviral infection, experiments were performed as previously reported 20 . The peak of viral expression in the hypothalamus was observed from Day 5 to 9 as previously reported 20 …”

Section: Methodsmentioning

confidence: 92%

Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway

Zhou

Wang

et al. 2020

FASEB j.

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The role of central juxtaposed with another zinc finger gene 1 (JAZF1) in glucose regulation remains unclear. Here, we activated mediobasal hypothalamus (MBH) JAZF1 in high-fat diet (HFD)-fed rats by an adenovirus expressing JAZF1 (Ad-JAZF1). We evaluated the changes in the hypothalamic insulin receptor (InsR)-PI3K-Akt-AMPK pathway and hepatic glucose production (HGP). To investigate the impact of MBH Ad-JAZF1 on HGP, we activated MBH JAZF1 in the presence or absence of ATPdependent potassium (K ATP ) channel inhibition, hepatic branch vagotomy (HVG), or an AMPK activator (AICAR). In HFD-fed rats, MBH Ad-JAZF1 decreased body weight and food intake, and inhibited HGP by increasing hepatic insulin signaling. Under insulin stimulation, MBH Ad-JAZF1 increased InsR and Akt phosphorylation, and phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) formation; however, AMPK phosphorylation was decreased in the hypothalamus. The positive effect of MBH JAZF1 on hepatic insulin signaling and HGP was prevented by treatment with | 7059 ZHOU et al.

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Section: Methodsmentioning

confidence: 92%

Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway

Zhou

Wang

et al. 2020

FASEB j.

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“…In addition to triglyceride metabolism, JAZF1 has been shown to play a role in cholesterol synthesis. This result may be explained by the fact that JAZF1 suppresses 3‐hydroxy‐3methylglutaryl coenzyme A reductase (HMGCR) promoter transcriptional activity via dephosphorylation of cAMP‐response element binding protein (CREB) on Ser133 . From the above data, JAZF1 may serve as a biomarker of lipid catabolism in liver and AT.…”

Section: The Potential Roles Of Jazf1 On Treatment Of T2dmmentioning

confidence: 99%

JAZF1, a relevant metabolic regulator in type 2 diabetes

Liao

Wang

et al. 2019

Diabetes Metabolism Res

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Excessive adiposity and metabolic inflammation are the key risk factors of type 2 diabetes mellitus (T2DM). Juxtaposed with another zinc finger gene 1 (JAZF1) has been identified as a novel transcriptional cofactor, with function of regulating glucose and lipid homeostasis and inflammation. JAZF1 is involved in metabolic process of T2DM via interaction with several nuclear receptors and protein kinases. Additionally, increasing evidence from genome-wide association studies (GWAS) has shown that JAZF1 polymorphisms are closely associated with T2DM. In this review, we have updated the latest research advances on JAZF1 and discussed its regulatory network in T2DM. The association between JAZF1 polymorphisms and T2DM is discussed as well. The information provided is of importance for guiding future studies as well as for the design of JAZF1-based T2DM therapy.

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“…LZTFL1, expression in epithelial cells of various tissues such as the lung, is down-regulated in some tumors [44]. Overexpression of JAZF1 protected against the development of atherosclerosis in mice [45]. Mice that lacks THBS2 developed a complex phenotype characterized by abnormalities in connective tissues and fibroblast adhesion, elevated endosteal bone growth and an increase in vascular density [46].…”

Section: Discussionmentioning

confidence: 99%

Dysregulated expression of microRNAs and mRNAs in pulmonary artery remodeling in ascites syndrome in broiler chickens

Liu

Yang

et al. 2016

Oncotarget

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Ascites syndrome (AS), also known as pulmonary artery hypertension, remains a challenging disease that severely affects both humans and broiler chickens. Pulmonary artery remodeling presents a key step in the development of AS. In this study, we obtained pulmonary artery tissues from broilers with and without AS to perform miRNA sequencing analysis, miRNA-mRNA association analysis and pathological examinations. 29 significantly differentially expressed miRNAs were found both in known and novel miRNAs with 18 up-regulated and 11 down-regulated miRNAs. Their predicted potential targets were involved in a wide range of functional clusters as indicated via GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) analyses. The upregulation of miR-155, miR-23b-3p, miR-146b-5p and miR-146b-3p were found closely associated with the pathogenesis of pulmonary artery remodeling in AS progression. The association analysis for the miRNAs-mRNAs showed that these 29 significantly differentially expressed miRNAs regulate 162 differentially expressed target genes. Among them, 20 miRNAs correlated with 18 predicted target genes that appear to be involved in pulmonary artery remodeling, mainly in three broad physiological processes: the hypoxia sensing response (HIF1a, NHE1, STAT5 and STAT3), endothelial permeability dysfunction (CD44, TRAF2, CDK2AP1, LZTFL1, JAZF1, PEBP1, LRP1B, RPS14 and THBS2) and inflammation (MEOX2, STAT5, STAT3, IRF8, MAP3K8, IL-1BETA and TNFRSF1B). Pathological pulmonary artery remodeling in the AS broilers was consistently observed in the present study. Taken together, the current analysis further illuminates the molecular mechanism of pulmonary artery remodeling underlying AS progression.

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Overexpression of JAZF1 protected ApoE-deficient mice from atherosclerosis by inhibiting hepatic cholesterol synthesis via CREB-dependent mechanisms

Cited by 28 publications

References 32 publications

Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway

Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway

JAZF1, a relevant metabolic regulator in type 2 diabetes

Dysregulated expression of microRNAs and mRNAs in pulmonary artery remodeling in ascites syndrome in broiler chickens

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