Abstract:Purpose: Chronic kidney disease and progression to end-stage renal disease (ESRD) impose a significant burden on the health care system. Diabetic nephropathy (DN) accounts for a staggering 45% of all ESRD cases. As the number of individuals with diagnosed diabetes age Ն 20 years is expected to reach 39 million in 2050, the number of diabetes-related ESRD cases is expected to dramatically rise. Unfortunately, current management can delay but not cure DN. Integrins and their corresponding matrix proteins are inc… Show more
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