Overexpression of Id-1 is significantly associated with tumour angiogenesis in human pancreas cancers

Abstract

It has been suggested that Id-1 has a critical role in the tumour progression and aggressiveness of several human cancers. However, the clinicopathological and biological significance of Id-1 overexpression remains unclear in human primary cancer. To investigate the association between Id-1 expression and cell proliferation or tumour angiogenesis, we examined the cell cycle kinetic indices (the proliferation and apoptotic indices, PI and AI) and intratumoral microvessel density (MVD) in 65 human pancreatic cancers. We also investigated the relationship between its expression and various clinicopathological factors to determine the clinical significance of Id-1 overexpression. Out of a total 65 cases, 32 (49.3%) showed overexpression of Id-1 vs normal tissues. Id-1 expression was found to be significantly associated with MVD (P ¼ 0.002). In further analysis of subgroups with higher and lower Id-1 expression, tumours with higher Id-1 expression (scores 4 and 5) showed significantly higher MVD than tumours with lower expression of Id-1 (scores 2 and 3) (111.18757.14 vs 64.13728.19, Po0.001). However, no significant association was found between Id-1 overexpression and patient survival rate. No significant association was also found between Id-1 expression and cell cycle kinetic indices (PI or AI) in pancreatic cancer. Moreover, the overexpression of Id-1 protein was not correlated with any significant clinicopathologic factors. These findings indicate that Id-1 overexpression is closely related with tumour angiogenesis and a higher density of intratumoral vessel, but that it is not associated with a poorer prognosis of survival or a higher cell proliferative potential in human pancreatic cancer.

Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma

“…Another breast cancer study found a negative prognostic impact of increased ID1 expression . Similar results have been published regarding pancreatic cancer (Lee et al, 2004), cervical cancer (Schindl et al, 2001), and ovarian carcinomas . In these studies, stronger ID1 expression was consistently associated with poorly differentiated tumours and a more aggressive behaviour.…”

Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma

“…Overexpression of Id-1 in prostate cancer cells also promotes metastasis through increased angiogenesis and invasiveness (Coppe et al, 2004). Reduced expressions of Id-1 and Id-3 have been demonstrated to inhibit the metastatic ability of gastric cancer cells (Tsuchiya et al, 2005), and Id-1 expression has been shown to be associated with the presence of invasion in endometrial carcinoma (Takai et al, 2001) and tumour angiogenesis in human pancreatic cancer (Lee et al, 2004). In lines with these results, we found that primary ESCC at M1 stage had a significantly (P ¼ 0.012) higher nuclear expression of Id-1 than the M0 stage tumours.…”

ID1 Facilitates the Growth and Metastasis of Non-Small Cell Lung Cancer in Response to Nicotinic Acetylcholine Receptor and Epidermal Growth Factor Receptor Signaling

“…ID1's proliferative and antiapoptotic functions have been correlated with the onset and progression of a variety of human tumors, including those of mammary gland and pancreas (28); indeed, its overexpression is significantly associated with increased tumor angiogenesis and worse prognosis in these cancers (3,33). It has been shown that ID1 was essential for the metastasis of cancers to the lung in mouse models of cancer (13,18).…”