Overexpression of hsa_circ_0002874 promotes resistance of non-small cell lung cancer to paclitaxel by modulating miR-1273f/MDM2/p53 pathway

Xu, Jiachao; Ni, Liwei; Zhao, Fu-Jun; Dai, Xingliang; Ji, Tao; Pan, Jia Hao; Shi, Aiming; Shen, Zhu; Su, Cunjin; Zhang, Yusong

doi:10.18632/aging.202521

Cited by 26 publications

(27 citation statements)

References 38 publications

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“…They constructed a drug-resistant xenograft mouse model by subcutaneous injection of A549 lung/Taxol-resistant cells, and mice were treated for 10 days with agomir-1273f plus PTX, siRNAs directed to circRNA (siRNAs-ciR) plus PTX, or PTX alone. The tumor size in the agomir-1273f group and siRNAs-ciR group were significantly smaller than those in the PTX group, highlighting the relevance of the hsa_circ_0002874/miR1273f/MDM2/p53 pathway on PTX resistance in vivo [61].…”

Section: Circrnas In the Drug Resistancementioning

confidence: 87%

“…Recently, high expression of hsa_circ_0002874 has been evidenced in NSCLC [61] and predicted an advanced TNM stage. Interestingly, hsa_circ_0002874 acts by sequestering miR-1273f, which targets the MDM2/p53 pathway [61]. Furthermore, the authors assessed the important role of hsa_circ_0002874/miR-1273f axis on PTX resistance in NSCLC.…”

Section: Circrnas In the Drug Resistancementioning

confidence: 99%

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New Molecular Mechanisms and Clinical Impact of circRNAs in Human Cancer

Fontemaggi

Turco

Esposito

et al. 2021

Cancers

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Next generation RNA sequencing techniques, implemented in the recent years, have allowed us to identify circular RNAs (circRNAs), covalently closed loop structures resulting in RNA molecules that are more stable than linear RNAs. This class of non-coding RNA is emerging to be involved in a variety of cell functions during development, differentiation, and in many diseases, including cancer. Among the described biological activities, circRNAs have been implicated in microRNA (miRNA) sequestration, modulation of protein–protein interactions and regulation of mRNA transcription. In human cancer, circRNAs were implicated in the control of oncogenic activities such as tumor cell proliferation, epithelial-mesenchymal transition, invasion, metastasis and chemoresistance. The most widely described mechanism of action of circRNAs is their ability to act as competing endogenous RNAs (ceRNAs) for miRNAs, lncRNAs and mRNAs, thus impacting along their axis, despite the fact that a variety of additional mechanisms of action are emerging, representing an open and expanding field of study. Furthermore, research is currently focusing on understanding the possible implications of circRNAs in diagnostics, prognosis prediction, effectiveness of therapies and, eventually, therapeutic intervention in human cancer. The purpose of this review is to discuss new knowledge on the mechanisms of circRNA action, beyond ceRNA, their impact on human cancer and to dissect their potential value as biomarkers and therapeutic targets.

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Section: Circrnas In the Drug Resistancementioning

confidence: 87%

Section: Circrnas In the Drug Resistancementioning

confidence: 99%

New Molecular Mechanisms and Clinical Impact of circRNAs in Human Cancer

Fontemaggi

Turco

Esposito

et al. 2021

Cancers

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“…Bioinformatics analysis showed that most of the 31 DEmRNAs in IDD were associated with cell adhesion and cell exosome, and the phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway was involved in the pathogenesis of IDD. The downregulation of hsa-circ-0002874 [ 43 ] could regulate the miR1273f/MDM2/P53 signaling pathway to reverse the paclitaxel (PTX) resistance of non-small-cell lung cancer (NSCLC) and induce apoptosis. The expression of hsa-circ-0000554 was found to be enhanced in esophageal cancer tissues and radioresistant esophageal cancer tissues [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Construction of a Potentially Functional circRNA-miRNA-mRNA Network in Intervertebral Disc Degeneration by Bioinformatics Analysis

Huo

Tian

et al. 2021

BioMed Research International

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Background. The competing endogenous RNA- (ceRNA-) mediated regulatory mechanisms are known to play a pivotal role in intervertebral disc degeneration (IDD). Our research intended to establish a ceRNA regulatory network related to IDD through bioinformatics analyses. Methods. The expression profiles of circRNA, miRNA, and mRNA were obtained from the public Gene Expression Omnibus (GEO) datasets. Then, we use sequence-based bioinformatics methods to select differentially expressed mRNAs (DEmRNAs), microRNAs (DEmiRNAs), or circRNAs (DEcircRNAs) related to IDD. We used ChEA3 to verify the targets of transcription factors (TFs). Then, we used DAVID to annotate the DEmRNAs. Finally, we constructed a potentially circRNA-miRNA-mRNA network related to IDD by predicting in the database (ENCORI, TargetScan, miRecords, miRmap, and circBank). Results. We identified 31 common DEmRNAs by Venn analysis, of which MMP2 was regarded as the key hub genes. Simultaneously, miR-423-5p and miR-185-5p were predicted as the upstream molecules of MMP2. Furthermore, a total of six DEcircRNAs were predicted as the upstream circRNAs of miR-423-5p and miR-185-5p. Then, a potential circRNA-miRNA-mRNA network related to IDD was constructed by bioinformatics analysis. Conclusion. A comprehensive ceRNA regulatory network was constructed, which was found to be significant in IDD progression.

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“…For instance, circPKNOX1 influences progression of intervertebral disc disease by regulating KIAA0355 expression via miR-370-3p [ 23 ]. Downregulation of hsa_circ_0002874 regulates the miR1273f/MDM2/P53 signaling pathway to reverse paclitaxel resistance of non-small-cell lung cancer and induces apoptosis in vitro and in vivo [ 24 ]. hsa_circ_0107593 exhibits tumor-suppressing activity in cervical cancer by physically binding to hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Differential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis

Pan

Chen

Yan

et al. 2021

BioMed Research International

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Circular RNAs (circRNAs), a novel type of noncoding RNAs, have been demonstrated to behave as microRNA (miRNA) sponges to exert their effects during pathological processes of diseases. However, the roles of circRNAs have not been explored in necrotizing enterocolitis (NEC). This study sought to identify differentially expressed circRNAs and predict their potential biological functions in NEC. circRNA expression profiles in terminal ileum from newborn rats with NEC and normal controls were explored using next-generation sequencing. In the NEC group, 53 circRNAs were significantly differentially expressed, including 9 upregulated and 44 downregulated. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted, and circRNA-miRNA interaction networks were generated to predict the potential roles of circRNAs in NEC progression. Further investigation revealed that most circRNAs include miRNA binding sites and that some are implicated in NEC development. In conclusion, this study’s findings demonstrate that differentially expressed circRNAs are involved in NEC development via their interactions with miRNAs, making them prospective targets for NEC diagnosis and treatment.

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Overexpression of hsa_circ_0002874 promotes resistance of non-small cell lung cancer to paclitaxel by modulating miR-1273f/MDM2/p53 pathway

Cited by 26 publications

References 38 publications

New Molecular Mechanisms and Clinical Impact of circRNAs in Human Cancer

New Molecular Mechanisms and Clinical Impact of circRNAs in Human Cancer

Construction of a Potentially Functional circRNA-miRNA-mRNA Network in Intervertebral Disc Degeneration by Bioinformatics Analysis

Differential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis

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