Overexpression of hsa-miR-186 induces chromosomal instability in arsenic-exposed human keratinocytes

Wu, Jiguo; Cardoso, Ana Paula Ferragut; States, Vanessa; Al-Eryani, Laila; Doll, Mark A.; Wise, Sandra S.; Shesh, N.; States, J. Christopher

doi:10.1016/j.taap.2019.114614

Cited by 18 publications

(22 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent evidence suggests the role of miRNAs in genomic instability of cancer cells [ 63 ]. Low expression level of miR-137 was accompanied by increased frequency of IgH translocations in MM [ 63 ], up-regulation of miR-22 and miR-150 increased genomic instability in CML patients by decreasing the activity of an alternative form of nonhomologous end-joining (NHEJ) [ 64 ], and increased expression level of miR-186 resulted in chromosomal instability of arsenic-exposed human keratinocytes [ 65 ].…”

Section: Implication Of Mirnas In Carcinogenesis and Leukemogenesismentioning

confidence: 99%

Implication of microRNAs in Carcinogenesis with Emphasis on Hematological Malignancies and Clinical Translation

Gaál

2022

IJMS

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs, that are involved in the multistep process of carcinogenesis, contributing to all established hallmarks of cancer. In this review, implications of miRNAs in hematological malignancies and their clinical utilization fields are discussed. As components of the complex regulatory network of gene expression, influenced by the tissue microenvironment and epigenetic modifiers, miRNAs are “micromanagers” of all physiological processes including the regulation of hematopoiesis and metabolic pathways. Dysregulated miRNA expression levels contribute to both the initiation and progression of acute leukemias, the metabolic reprogramming of malignantly transformed hematopoietic precursors, and to the development of chemoresistance. Since they are highly stable and can be easily quantified in body fluids and tissue specimens, miRNAs are promising biomarkers for the early detection of hematological malignancies. Besides novel opportunities for differential diagnosis, miRNAs can contribute to advanced chemoresistance prediction and prognostic stratification of acute leukemias. Synthetic oligonucleotides and delivery vehicles aim the therapeutic modulation of miRNA expression levels. However, major challenges such as efficient delivery to specific locations, differences of miRNA expression patterns between pediatric and adult hematological malignancies, and potential side effects of miRNA-based therapies should be considered.

show abstract

Section: Implication Of Mirnas In Carcinogenesis and Leukemogenesismentioning

confidence: 99%

Implication of microRNAs in Carcinogenesis with Emphasis on Hematological Malignancies and Clinical Translation

Gaál

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…The role of miR-186 overexpression in the presence and absence of arsenite has been investigated (Wu, Ferragut Cardoso et al 2019). Arsenic exposure is known to introduce CIN via interference with DNA damage repair and disruption of mitotic progression (States 2015, Sage, Minatel et al 2017.…”

Section: Downloaded Frommentioning

confidence: 99%

The Role of Non-Coding RNAs in Chromosomal Instability in Cancer

Mohapatra

Winkle

Ton

et al. 2022

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Chromosomal instability (CIN) is characterized by an increased frequency of changes in chromosome structure or number and is regarded as a hallmark of cancer. CIN plays a prevalent role in tumorigenesis and cancer progression by assisting the cancer cells' phenotypic adaptation to stress, which has been tightly linked to therapy resistance and metastasis. Both, CIN-inducing and CIN-repressing agents are being clinically tested for the treatment of cancer to increase CIN levels to unsustainable levels leading to cell death, or to decrease CIN levels to limit the development of drug resistance, respectively. Noncoding RNAs (ncRNAs) including micro RNAs (miRNAs) and long noncoding RNAs (lncRNAs) have been fundamentally implicated in CIN. The miR-22, miR-26a, miR-28, miR-186 target important checkpoint proteins involved in mediating chromosomal stability and their expression modulation has been directly related to CIN occurrence. LncRNAs derived from telomeric, centrosomal and enhancer regions play an important role in mediating genome stability, while specific lncRNA transcripts including Ginir, GUARDIN, CCAT2, PCAT2, and NORAD have been shown to act within CINassociated pathways. In this review, we discuss how these ncRNAs either maintain or disrupt the stability of chromosomes and how these mechanisms could be exploited for novel therapeutic approaches targeting CIN in cancer patients.

show abstract

“…Of interest, recent evidence has implicated miRNA in the regulation of genomic instability, and therefore presents great potential in cancer therapy [83][84][85]. However, there are very few reports about miRNAs' involvement in MM progression by regulating genomic instability pathways.…”

Section: Roles Of Mirna In Regulating Genomic Instability In MMmentioning

confidence: 99%

Roles of miRNA dysregulation in the pathogenesis of multiple myeloma

et al. 2021

View full text Add to dashboard Cite

Multiple myeloma (MM) is a malignant disease of plasma cells with complex pathology, causing significant morbidity due to its end-organ destruction. The outcomes of patients with myeloma have significantly improved in the past couple of decades with the introduction of novel agents, such as proteasome inhibitors, immunomodulators, and monoclonal antibodies. However, MM remains incurable and presents considerable individual heterogeneity. MicroRNAs (miRNAs) are short, endogenous noncoding RNAs of 19–22 nucleotides that regulate gene expression at the posttranscriptional level. Numerous studies have shown that miRNA deregulation is closely related to MM pathology, including tumor initiation, progression, metastasis, prognosis, and drug response, which make the complicated miRNA network an attractive and marvelous area of investigation for novel anti-MM therapeutic approaches. Herein, we mainly summarized the current knowledge on the roles of miRNAs, which are of great significance in regulating pathological factors involved in MM progressions, such as bone marrow microenvironment, methylation, immune regulation, genomic instability, and drug resistance. Meanwhile, their potential as novel prognostic biomarkers and therapeutic targets was also discussed.

show abstract

Overexpression of hsa-miR-186 induces chromosomal instability in arsenic-exposed human keratinocytes

Cited by 18 publications

References 59 publications

Implication of microRNAs in Carcinogenesis with Emphasis on Hematological Malignancies and Clinical Translation

Implication of microRNAs in Carcinogenesis with Emphasis on Hematological Malignancies and Clinical Translation

The Role of Non-Coding RNAs in Chromosomal Instability in Cancer

Roles of miRNA dysregulation in the pathogenesis of multiple myeloma

Contact Info

Product

Resources

About