Overexpression of HER-2/neu in Patients with Prostatic Adenocarcinoma

Zahir, Shokouh Taghipour; Tafti, Hamid Fallah; Rahmani, Koorosh

doi:10.7314/apjcp.2014.15.15.6425

Cited by 9 publications

(11 citation statements)

References 19 publications

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“…The expression of HER-2 in the primary tumor was positive (≥10% expressing HER-2) in 20.8% of cases, which is similar to that reported by other authors (Zahir et al, 2014). There was no association with the Gleason score or pathological stage, which is similar to some reports (Lara et al, 2002;Zahir et al, 2014).…”

Section: Discussionsupporting

confidence: 90%

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Possible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence

Murray

Reyes²,

Fuentealba³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 90%

“…There was no association with the Gleason score or pathological stage, which is similar to some reports (Lara et al, 2002;Zahir et al, 2014). However other studies have reported an association with the Gleason score, HER-2 expression being higher in patients with a Gleason score >7 (Neto et al, 2010).…”

Section: Discussionsupporting

confidence: 88%

Possible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence

Murray

Reyes²,

Fuentealba³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Но есть также данные, показывающие, что высокая экспрессия определенного рецептора из семейства HER определяет гистологический тип опухоли, например при раке желудка [4], а также влияет на выживаемость пациентов, в особенности отмечается, что гиперэкспрессия HER-3 при раке желудка приводит к ухудшению состояния больных и снижает их выживаемость [4,16]. Высокая экспрессия HER-2 при аденокарциноме простаты коррелирует с уровнем сывороточного простатического специфического антигена и может играть важную роль в прогрессировании заболевания [55]. Долгое время считалось, что НЕР3 не обладает киназной активностью, однако недавно обнаружили, что эти рецепторы проявляют активность тирозинкиназы и образуют гомодимеры и гетеродимеры с другими НЕР рецепторами.…”

Section: факторы ростаunclassified

Expression Density of Receptors to Immunoregulatory Mediators as a Modulating Component of Biological Effects of Mediators on Cell. Part 1

et al. 2019

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The present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors and tumor necrosis factors), the variants are presented for participation of receptors as components of cytokine/cell interaction, as proven by in vitro and in vivo studies. Ability of the receptors expression to modify characteristics and type of these interactions is shown. The data on participation of receptors for regulatory molecules in development of immune-mediated diseases of various genesis have been analyzed. It was demonstrated that the changes in the receptor expression are of great importance when evaluating functional response of the cells to the mediators and in development of pathological conditions. Current studies confirmed the data suggesting effects of receptor density upon the processes of proliferation and apoptosis, as well as metabolic processes that trigger development of autoimmune, oncological and dystrophic diseases. For all the considered classes of regulatory molecules, the change in the density of receptor expression is one of the key aspects in regulating functional activity of the cells. Thus, studying expression levels of receptors on the cell membrane is important in understanding pathogenesis, whereas changing expression level may be considered as a therapeutic target in the treatment of various diseases.

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“…In statistical analysis, score of + 2 and + 3 was considered as overexpression of HER2/neu according to the scoring criteria provided by the DAKO company. [20]…”

Section: Prognostic Markermentioning

confidence: 99%

Correlation of Gleason Grading and Prognostic Immunohistochemistry Markers (Human Epidermal Growth Factor Receptor 2/neu and Androgen Receptor) in Prostatic Core Needle Biopsy: A Study in a Tertiary Care Center

Senapati

Sengupta

Datta

et al. 2019

Indian Journal of Medical and Paediatric Oncology

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Background: Worldwide prostate cancer is the most common cause of cancer and the second leading cause of cancer death among men. Transrectal ultrasound-guided core needle biopsies are the diagnostic modalities which help in proper categorization and grading of prostatic carcinoma, thus facilitating individualized treatment. These biopsies are the primary source for performance of additional diagnostic immunohistochemical testing for basal cell-associated markers to rule out the morphological mimicker and prognostic markers such as androgen receptor (AR) and human epidermal growth factor receptor 2 (HER2)/neu. Materials and Methods: A prospective, observational study was conducted in the department of pathology in collaboration with department of urosurgery of a tertiary care hospital. One hundred and nineteen patients diagnosed with prostatic nodules were included in this study. Values of serum prostate-specific antigen were recorded. Tissue for histopathological study was obtained in the form of core needle biopsy, and Gleason grade was calculated in all malignant cases. Immunohistochemistry for p63 and alpha-methylacyl-CoA racemase was performed as an additional test in premalignant cases. Prognostication of the prostate cancer cases was done using AR and HER2/neu. Results: A total of 119 cases aged between 20 and 90 years were included in this study. Malignant lesions reveal an increase in the percentage of AR staining in comparison to the benign glandular structure. The Gleason score with higher value (8–9) showed increased expression of HER2/neu receptor. Conclusion: Critical histopathological analysis of core needle biopsy along with immunohistochemical evaluation maximizes the diagnostic accuracy in prostate cancer cases and also helps in prognosis assessment.

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Overexpression of HER-2/neu in Patients with Prostatic Adenocarcinoma

Cited by 9 publications

References 19 publications

Possible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence

Possible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence

Expression Density of Receptors to Immunoregulatory Mediators as a Modulating Component of Biological Effects of Mediators on Cell. Part 1

Correlation of Gleason Grading and Prognostic Immunohistochemistry Markers (Human Epidermal Growth Factor Receptor 2/neu and Androgen Receptor) in Prostatic Core Needle Biopsy: A Study in a Tertiary Care Center

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