2018
DOI: 10.2147/ott.s175606
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Overexpression of GPR35 confers drug resistance in NSCLC cells by β-arrestin/Akt signaling

Abstract: BackgroundNon-small-cell lung cancer (NSCLC) is the major leading cause of cancer-related death around the world. The resistance to chemotherapy limits the effects of clinical treatment. The aim of this study was to identify novel mechanisms involved in NSCLC chemoresistance.Materials and methodsWe explored the public database and commercial tissue microarray to evaluate the expression of G protein-coupled receptor 35 (GPR35). We established the chemoresistant A549 cell line to further investigate the biologic… Show more

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Cited by 25 publications
(21 citation statements)
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References 34 publications
(31 reference statements)
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“…In the present study, the expression levels of CXCL17 and CXCR8 were higher in colon cancer tissues compared with healthy tumour-adjacent tissues. This finding was consistent with previous studies on CXCL17 in colon cancer (8), as well as CXCR8 in breast cancer (15) and lung cancer (19). Recent studies performed at the mRNA level suggested that both CXCL17 (20) and CXCR8 (21) were ectopically expressed in primary colon cancer tissues and regional positive lymph nodes.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…In the present study, the expression levels of CXCL17 and CXCR8 were higher in colon cancer tissues compared with healthy tumour-adjacent tissues. This finding was consistent with previous studies on CXCL17 in colon cancer (8), as well as CXCR8 in breast cancer (15) and lung cancer (19). Recent studies performed at the mRNA level suggested that both CXCL17 (20) and CXCR8 (21) were ectopically expressed in primary colon cancer tissues and regional positive lymph nodes.…”
Section: Discussionsupporting
confidence: 92%
“…A recent study revealed that CXCL17 in HCC mediates the invasion of malignant cells (22). In addition, high GPR35 expression correlates with drug resistance in lung cancer (19). Compared with studies on other malignancies, high CXCL17 and CXCR8 expression in the present study was associated with different outcomes, as patients with high expression had an improved prognosis.…”
Section: Genecontrasting
confidence: 59%
“…GPR35 protein expression was significantly elevated in primary tumour tissue of non-small-cell lung cancer as compared to normal lung, and high expression levels correlated with poor prognosis. 27 In contrast, although GPR35 protein expression in breast cancer primary tumours was increased, it did not correlate with poor prognosis. 10 Our results in CC primary tumours are similar to those in breast cancer.…”
Section: Discussionmentioning
confidence: 91%
“… 7 In nonsmall cell lung cancer (NSCLC), overexpression of GPR35 is associated with poor prognosis in patients, and GPR35 knockdown significantly overcomes chemoresistance in NSCLC in vitro and in vivo . 55 Such data imply that GPR35 may facilitate cancer growth and metastasis and, potentially, serve as a clinical tumor marker. It is, therefore, of considerable interest to investigate the significance, signaling and function of GPR35 in late stages of cancers more fully.…”
Section: Potential Therapeutic Opportunitiesmentioning
confidence: 99%