2019
DOI: 10.1016/j.ijbiomac.2018.11.032
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Overexpression of G2 and S phase-expressed-1 contributes to cell proliferation, migration, and invasion via regulating p53/FoxM1/CCNB1 pathway and predicts poor prognosis in bladder cancer

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Cited by 49 publications
(52 citation statements)
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“…GTSE1 has been found to be highly expressed in the tumors such as melanoma and lung cancer and is related to the weak prognosis of the patients (Wu et al, 2017;Xu et al, 2018). Additionally, GTSE1 might be participating in tumorigenesis and progression by modulating p53 phosphorylation (Liu et al, 2010(Liu et al, , 2019.…”
Section: Discussionmentioning
confidence: 99%
“…GTSE1 has been found to be highly expressed in the tumors such as melanoma and lung cancer and is related to the weak prognosis of the patients (Wu et al, 2017;Xu et al, 2018). Additionally, GTSE1 might be participating in tumorigenesis and progression by modulating p53 phosphorylation (Liu et al, 2010(Liu et al, , 2019.…”
Section: Discussionmentioning
confidence: 99%
“…Emerging evidence indicated abnormal expression of genes in cell cycle, and apoptosis regulation, like p53, Rb, p27, and TGFβ/IGF2R, is related to etiopathogenesis and prognosis of liver cancer patients [1]. GTSE1 has been demonstrated as a potential biomarker for poor clinical outcome in several types of cancer [10,13,27]. Previous research suggested GTSE1's functional role in hepatocellular carcinoma (HCC) proliferation, colony formation, invasion, and overall survival [9,13].…”
Section: Discussionmentioning
confidence: 99%
“…While in normal condition, GTSE1 is activated by functional p53 binding on the GTSE1 promoter region and encodes GTSE1 protein to cause a delay from G2 to M transition [3,8]. Recent studies revealed that overexpression of GTSE1 contributes to promoting cell proliferation, migration, and invasion in different cancers via translocalizing p53 to the cytoplasm [9,10].…”
Section: Introductionmentioning
confidence: 99%
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“…It has been reported that GTSE1 is highly expressed in tumors such as liver cancer and melanoma, and is associated with poor prognosis of patients [18,19]. Moreover, GTSE1 may be involved in tumorigenesis and progression by regulating p53 phosphorylation [20,21]. In another liver cancer study, it was also proved that the down-regulation of GTSE1 has a good effect of promoting apoptosis, reducing anti-apoptotic ability and enhancing the sensitivity of chemotherapeutic drugs [22].…”
Section: Gepia Analysismentioning
confidence: 99%