Overexpression of Estrogen Receptor α in Mammary Glands of Aging Mice Is Associated with a Proliferative Risk Signature and Generation of Estrogen Receptor α–Positive Mammary Adenocarcinomas

Furth, Priscilla A.; Wang, Weisheng; Kang, Keunsoo; Rooney, Brendan; Keegan, Grace; Muralidaran, Vinona; Wong, John Chee Meng; Shearer, Charles; Zou, Xiaojun; Flaws, Jodi A.

doi:10.1016/j.ajpath.2022.09.008

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2024

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“…5 (a), the subpathways are up-regulated in the high-risk group. Interestingly, overexpression of CCNB1 , MYBL2 , and ESR1 , promoting cell proliferation, can lead to higher recurrence risks [39] , [45] . To further examine the prognostic potential of the top-3 subpathways, we conducted survival analyses and a simulation study assuming a targeted therapy situation.…”

Section: Resultsmentioning

confidence: 99%