Overexpression of Epithelial Splicing Regulatory Protein 1 in Metastatic Lesions of Serous Ovarian Carcinoma Correlates with Poor Patient Prognosis

Lu, Xinxin; Li, Runzhou; Wang, Xing-shuang; Guo, Qi; Wang, Ling; Zhou, Xin

doi:10.1089/cbr.2021.0215

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…It was reported that cold exposure increases intestinal paracellular permeability to nutrients in mice, which was associated with a transient increase in the expression of CLDN2 [ 66 ]. In addition, myosins (MYO1E, MYO5B, MYO6) are actin-based motor molecules serve in intracellular movements; epithelial splicing regulatory protein 1 (ESPR1) regulates the formation of epithelial-cell-specific isoforms; and syntaxin-19 (STX19) plays a role in endosomal trafficking of the epidermal growth factor receptor [ 67 , 68 , 69 ]. These hub genes were also correlated in the network from the cytoskeleton and anatomical structure functions ( Figure 6 ), which, together with CLDNs and OCLNs, could contribute to the maintenance of the cellular structure of P. olivaceus gills and livers under cold stress ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Transcriptomic Networks Reveal the Tissue-Specific Cold Shock Responses in Japanese Flounder (Paralichthys olivaceus)

Zhu

Han

et al. 2023

Biology

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Low temperature is among the important factors affecting the distribution, survival, growth, and physiology of aquatic animals. In this study, coordinated transcriptomic responses to 10 °C acute cold stress were investigated in the gills, hearts, livers, and spleens of Japanese flounder (Paralichthys olivaceus), an important aquaculture species in east Asia. Histological examination suggested different levels of injury among P. olivaceus tissues after cold shock, mainly in the gills and livers. Based on transcriptome and weighted gene coexpression network analysis, 10 tissue-specific cold responsive modules (CRMs) were identified, revealing a cascade of cellular responses to cold stress. Specifically, five upregulated CRMs were enriched with induced differentially expressed genes (DEGs), mainly corresponding to the functions of “extracellular matrix”, “cytoskeleton”, and “oxidoreductase activity”, indicating the induced cellular response to cold shock. The “cell cycle/division” and “DNA complex” functions were enriched in the downregulated CRMs for all four tissues, which comprised inhibited DEGs, suggesting that even with tissue-specific responses, cold shock may induce severely disrupted cellular functions in all tissues, reducing aquaculture productivity. Therefore, our results revealed the tissue-specific regulation of the cellular response to low-temperature stress, which warrants further investigation and provides more comprehensive insights for the conservation and cultivation of P. olivaceus in cold water.

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Section: Resultsmentioning

confidence: 99%

Transcriptomic Networks Reveal the Tissue-Specific Cold Shock Responses in Japanese Flounder (Paralichthys olivaceus)

Zhu

Han

et al. 2023

Biology

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show abstract

Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression

Liu

et al. 2022

J Mol Med

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Overexpression of Epithelial Splicing Regulatory Protein 1 in Metastatic Lesions of Serous Ovarian Carcinoma Correlates with Poor Patient Prognosis

Cited by 2 publications

References 45 publications

Transcriptomic Networks Reveal the Tissue-Specific Cold Shock Responses in Japanese Flounder (Paralichthys olivaceus)

Transcriptomic Networks Reveal the Tissue-Specific Cold Shock Responses in Japanese Flounder (Paralichthys olivaceus)

Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression

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