Overexpression of DSPP promotes the proliferation and migration of astrocytes

Gao, Huasong; Fan, Shaochen; Xie, Lihui; Hu, Shukun; Zhang, Yi

doi:10.1016/j.neulet.2021.135775

Cited by 1 publication

(1 citation statement)

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“…It has been reported that dentin sialophosphoprotein (DSPP), a member of the small integrin-binding ligand N-linked glycoprotein family, interacts with β6 integrin to promote cell proliferation, differentiation, and migration [108]. In fact, overexpression of DSPP increased activation of the Akt/mTOR pathway in astrocytes, which might promote proliferation and migration of reactive astrocytes [109]. Thus, targeting DSPP appears to be an effective therapeutic strategy for treating CNS injury related to glial scar formation.…”

Section: Integrin Signaling In Reactive Astrocytesmentioning

confidence: 99%

Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases

Ikeshima-Kataoka

Sugimoto

Tsubokawa

2022

IJMS

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The integrin family is involved in various biological functions, including cell proliferation, differentiation and migration, and also in the pathogenesis of disease. Integrins are multifunctional receptors that exist as heterodimers composed of α and β subunits and bind to various ligands, including extracellular matrix (ECM) proteins; they are found in many animals, not only vertebrates (e.g., mouse, rat, and teleost fish), but also invertebrates (e.g., planarian flatworm, fruit fly, nematodes, and cephalopods), which are used for research on genetics and social behaviors or as models for human diseases. In the present paper, we describe the results of a phylogenetic tree analysis of the integrin family among these species. We summarize integrin signaling in teleost fish, which serves as an excellent model for the study of regenerative systems and possesses the ability for replacing missing tissues, especially in the central nervous system, which has not been demonstrated in mammals. In addition, functions of astrocytes and reactive astrocytes, which contain neuroprotective subpopulations that act in concert with the ECM proteins tenascin C and osteopontin via integrin are also reviewed. Drug development research using integrin as a therapeutic target could result in breakthroughs for the treatment of neurodegenerative diseases and brain injury in mammals.

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Section: Integrin Signaling In Reactive Astrocytesmentioning

confidence: 99%