Overexpression of Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin in Dendritic Cells Protecting against Aspergillosis

Li, Li-Yang; Zhang, Hao-Ru; Jiang, Zhilong; Chang, Yan‐Zhong; Shao, Chen

doi:10.4103/0366-6999.244103

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…[ 34 , 35 ] For example, after fungal infection, DCs capture the fungal particles and present antigens to T cells, which induce a specific Th1 adaptive immune response to fungus. [ 36 – 39 ] Pene et al [ 40 ] found that intratracheal administration of DC in mice with compromised immunity infected with Pseudomonas aeruginosa could significantly improve the survival of these mice. The similar results found by Bohannon et al [ 41 ] indicated that DC could accelerate the clearance of Pseudomonas aeruginosa in burned mice.…”

Section: Discussionmentioning

confidence: 99%

Role of immunodeficiency in Acinetobacter baumannii associated pneumonia in mice

Liu

Xie

et al. 2020

Chinese Medical Journal

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Background Acinetobacter baumannii ( A. baumannii ) has become one of the most important opportunistic pathogens inducing nosocomial pneumonia and increasing mortality in critically ill patients recently. The interaction between A. baumannii infection and immune response can influence the prognosis of A. baumannii related pneumonia. The target of the present study was to investigate the role of immunodeficiency in A. baumannii induced pneumonia. Methods Male BALB/c mice were randomly divided into the normal immunity control (NIC) group, normal immunity infection (NIA) group, immune compromised control (CIC) group, and immune compromised infection (CIA) group ( n = 15 for each group). Intraperitoneal injection of cyclophosphamide and intranasal instillation of A. baumannii solution were used to induce compromised immunity and murine pneumonia, respectively. The mice were sacrificed at 6 and 24 h later and the specimens were collected for further tests. Seven-day mortality of mice was also assessed. Results After A. baumannii stimulation, the recruitment of neutrophils in mice with normal immunity increased sharply ( P = 0.030 at 6 h), while there was no significant raise of neutrophil counts in mice with compromised immune condition ( P = 0.092 at 6 h, P = 0.772 at 24 h). The Th cell polarization presented with pulmonary interleukin (IL)-4 and interferon (IFN)-γ level in response to the A. baumannii in CIA group were significantly depressed in comparison with in NIA group (IFN-γ: P = 0.003 at 6 h; P = 0.001 at 24 h; IL-4: P < 0.001 at 6 h; P < 0.001 at 24 h). The pulmonary conventional dendritic cell accumulation was even found to be inhibited after A. baumannii infection in immunocompromised mice ( P = 0.033). Correspondingly, A. baumannii associated pneumonia in mice with compromised immunity caused more early stage death, more severe histopathological impairment in lung. Conclusion A. baumannii could frustrate the immune response in immunocompromised conditions, and this reduced immune response is related to more severe lung injury and worse outcome in A. baumannii induced pneumonia.

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Section: Discussionmentioning

confidence: 99%

Role of immunodeficiency in Acinetobacter baumannii associated pneumonia in mice

Liu

Xie

et al. 2020

Chinese Medical Journal

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“…The interferon-γ (IFN-γ) pathway is emerging as a key player in host immune response. [ 43 – 46 ] It plays a dual role in anti-tumor immune response. IFN-γ is produced by tumor-specific T cells, it induces an effective anti-tumor immune response by the following ways: (1) its direct anti-proliferative and pro-apoptotic effects on tumor cells; (2) enhancing the expression of MHC and other molecules to increase tumor antigen presentation; and (3) recruiting other immune cells.…”

Section: Mechanisms Of Resistance To Icismentioning

confidence: 99%

“…[ 95 , 96 ] In patients treated with PD-1 antibody, a new homozygous truncation mutation of β2M occurs in drug-resistant cells, resulting in lack of surface expression of HLA class I. [ 46 ] Direct loss of the gene encoding the HLA-C∗08:02 class I molecule was recently described in a colorectal tumor that progressed after initial response to T-cell transfer therapy. These T cells were HLA-C∗08:02-restricted TILs, and thus this mutation directly allowed immune evasion by tumor cells.…”

Section: Mechanisms Of Resistance To Icismentioning

confidence: 99%

“…In the other two recurrence cases, a copy number neutral functional deletion mutation was found in JAK1 or JAK2, concurrent with loss of heterozygosity in β2M. [ 46 ] These mutations in tumor cells lead to decreased sensitivity to IFN-γ, ultimately preventing IFN-γ-induced cell growth arrest. [ 46 ] Upon exposure to IFN-γ (produced by activated T cells), JAK1/2 becomes activated and subsequently phosphorylates a tyrosine residue present on STATs.…”

Section: Mechanisms Of Resistance To Icismentioning

confidence: 99%

“…[ 46 ] These mutations in tumor cells lead to decreased sensitivity to IFN-γ, ultimately preventing IFN-γ-induced cell growth arrest. [ 46 ] Upon exposure to IFN-γ (produced by activated T cells), JAK1/2 becomes activated and subsequently phosphorylates a tyrosine residue present on STATs. This JAK/STAT signaling pathway is responsible for cell proliferation, differentiation, cell migration, and apoptosis.…”

Section: Mechanisms Of Resistance To Icismentioning

confidence: 99%

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Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer

Qian

Han²

2020

Chinese Medical Journal

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In recent years, the research of immune checkpoint inhibitors has made a great breakthrough in lung cancer treatment. Currently, a variety of immune checkpoint inhibitors have been applied into clinical practice, including antibodies targeting the programmed cell death-1, programmed cell death-ligand 1, and cytotoxic T-lymphocyte antigen 4, and so on. However, not all patients can benefit from the treatment. Abnormal antigen presentation, functional gene mutation, tumor microenvironment, and other factors can lead to primary or secondary resistance. In this paper, we reviewed the molecular mechanism of immune checkpoint inhibitor resistance and various combination strategies to overcome resistance, in order to expand the beneficial population and enable precision medicine.

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PAMPs of the Fungal Cell Wall and Mammalian PRRs

Hatinguais

Willment

Brown

2020

Current Topics in Microbiology and Immunology

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Overexpression of Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin in Dendritic Cells Protecting against Aspergillosis

Cited by 8 publications

References 29 publications

Role of immunodeficiency in Acinetobacter baumannii associated pneumonia in mice

Role of immunodeficiency in Acinetobacter baumannii associated pneumonia in mice

Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer

PAMPs of the Fungal Cell Wall and Mammalian PRRs

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