Overexpression of Cyclin L2 Inhibits Growth and Enhances Chemosensitivity in Human Gastric Cancer Cells

Li, Hong Li; Ding, Huang; Deng, Ting; Zhou, Li; Wang, Xia; Bai, Ming; Ba, Yi

doi:10.7314/apjcp.2012.13.4.1425

Cited by 11 publications

(6 citation statements)

References 18 publications

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“…Li et al . observed that ectopic overexpression of CCNL1 exerted direct anti-proliferative effects on BCG823 gastric cancer cells and enhanced the chemosensitivity of these cells to fluorouracil, docetaxel and cisplatin by inducing cell cycle arrest and cell apoptosis 33 . These observations were consistent with the results of cell cycle and apoptosis analyses of SMMC7721 human hepatocellular carcinoma cells 34 .…”

Section: Discussionmentioning

confidence: 98%

Upregulation of MicroRNA-214 Contributes to the Development of Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Via Targeting CCNL2

Liu

Yin

Chen

et al. 2016

Sci Rep

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Hypoxia-induced pulmonary hypertension (PH), which is characterized by vascular remodeling of blood vessels, is a significant complication of chronic obstructive pulmonary disease (COPD). In this study, we screened 13 candidate miRNAs in pulmonary artery smooth muscle cells (PASMCs) harvested from COPD patients with PH (n = 18) and normal controls (n = 15) and found that the expression of miR-214 was differentially expressed between these two groups. Additionally, cyclin L2 (CCNL2) was validated as a target of miR-214 in PASMCs using a luciferase assay. Based on real-time PCR, immunohistochemistry and western blot, the expression of CCNL2 was substantially downregulated in PASMCs from COPD patients with PH compared with those from normal controls. Moreover, the relationship between miRNA and mRNA expression was confirmed using real-time PCR and western blot in PASMCs transfected with miR-214 mimics. Furthermore, the introduction of miR-214 significantly promoted the proliferation of PASMCs by suppressing cell apoptosis, and this effect was mediated by the downregulation of CCNL2. Exposure of PASMCs to hypoxia significantly increased the expression of miR-214, decreased the expression of CCNL2, and promoted cell proliferation. However, these effects were significantly attenuated by the introduction of miR-214 inhibitors, which significantly downregulated miR-214 expression and upregulated CCNL2 expression.

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Section: Discussionmentioning

confidence: 98%

Upregulation of MicroRNA-214 Contributes to the Development of Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Via Targeting CCNL2

Liu

Yin

Chen

et al. 2016

Sci Rep

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“…It has been shown that cisplatin resistance is associated with multifactorial mechanisms, such as inactivation by glutathione, metallothionein, or other sulphur-containing molecules, increased repair of DNA damage and Autophagy, reduced apoptosis and intracellular drug accumulation by changing the profile of drug-influx or -efflux molecules (Song et al, 2012;Galluzzi et al, 2012;Zhang et al, 2013). Many studies, concerned with the specific gene manipulation, have provided a way to make cancer cells specifically more sensitive to cisplatin (Hu et al, 2012;Li et al, 2012;Yu et al, 2013). However, the role of Med19 in chemotherapeutic drug resistance has not yet been established.…”

Section: 875 Knockdown Of Med19 Enhances Chemo-sensitivity To Cisplamentioning

confidence: 99%

Knockdown of Med19 Suppresses Proliferation and Enhances Chemo-sensitivity to Cisplatin in Non-small Cell Lung Cancer Cells

Wei¹,

Wang²,

Sun³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…CCNL2 is a novel member of the cyclin gene family. Studies have shown that it acts as a tumor suppressor protein in gastric cancer [ 41 ] and lung cancer [ 42 ]. This may also be validated in our pan-cancer analysis results.…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis to identify the AC005154.6/hsa-miR-29c-3p/CCNL2 axis as a novel prognostic biomarker associated with immune infiltration in prostate cancer

Chen

Song

et al. 2022

Cancer Cell Int

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Background Prostate cancer (PCa) is currently the major malignancy in men. It is becoming increasingly clear that competitive endogenous RNA (ceRNA) regulation networks are important in a wide variety of cancers. Nevertheless, there is still much to learn about the biological functions of the ceRNA network in prostate cancer. Methods The ceRNA network was constructed using the "GDCRNATools" package. Based on survival analysis, we obtained AC005154.6/hsa-miR-29c-3p/CCNL2 for further analysis. The prognostic model based on this ceRNA network was constructed by univariate and multivariate Cox regression methods. Furthermore, functional enrichment analysis, mutation landscape analysis, immune infiltration analysis, drug sensitivity analysis, methylation analysis, pan-cancer analysis, and molecular experiments of CCNL2 were carried out to investigate the role of CCNL2 in tumorigenesis. Results We identified the AC005154.6/CCNL2 axis as a risk factor that can promote the progression of prostate cancer by bioinformatics analysis and molecular experiments. Immune infiltration analysis suggested that CCNL2 may act as a novel biomarker for treatment decisions. The methylation level of CCNL2 was significantly decreased in tumor samples, possibly contributing to the upregulation of CCNL2 in prostate cancer. Moreover, CCNL2 is differentially expressed in multiple cancers and is tightly correlated with immune infiltration. Conclusion The current study constructed a ceRNA network, AC005154.6/hsa-miR-29c-3p/CCNL2. Potentially, this biomarker can be used for early diagnosis and decision-making about prostate cancer treatment.

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Overexpression of Cyclin L2 Inhibits Growth and Enhances Chemosensitivity in Human Gastric Cancer Cells

Cited by 11 publications

References 18 publications

Upregulation of MicroRNA-214 Contributes to the Development of Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Via Targeting CCNL2

Upregulation of MicroRNA-214 Contributes to the Development of Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Via Targeting CCNL2

Knockdown of Med19 Suppresses Proliferation and Enhances Chemo-sensitivity to Cisplatin in Non-small Cell Lung Cancer Cells

Integrated analysis to identify the AC005154.6/hsa-miR-29c-3p/CCNL2 axis as a novel prognostic biomarker associated with immune infiltration in prostate cancer

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