Overexpression of CXCL1 and its receptor CXCR2 promote tumor invasion in gastric cancer

Cheng, Wanli; Wang, C.-S.; Huang, Ya‐Hui; Tsai, Ming-Ming; Li, Ying; Lin, Kwang‐Huei

doi:10.1093/annonc/mdq739

Cited by 113 publications

(98 citation statements)

References 38 publications

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“…CXCL1 also mediated the metastasis of squamous cell carcinoma (21). In GC, CXCL1/CXCR2 upregulates MMP2, MMP9, N-Ras, K-Ras, signal transducer and activator of transcription 3 and promote the migratory and invasive abilities of tumor cells (8). The results of the present analysis revealed that high expression of CXCL1 is associated with tumor invasion and tumor metastasis and may act as an independent prognosis biomarker in GC.…”

Section: Overall Survival -----------------------------------------mentioning

confidence: 49%

“…CXCL1 was also found to contribute to prostate tumor cell migration and invasion through the activation of NF-κB (7). In GC, overexpression of CXCL1 and its receptor CXCR2 were found to be associated with tumor metastasis and a poor prognosis (8). However, the role of CXCL1 as a prognostic biomarker and the mechanism in tumor metastasis remain unknown.…”

Section: Introductionmentioning

confidence: 99%

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CXCL1 expression is correlated with Snail expression and affects the prognosis of patients with gastric cancer

et al. 2015

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Section: Overall Survival -----------------------------------------mentioning

confidence: 49%

Section: Introductionmentioning

confidence: 99%

CXCL1 expression is correlated with Snail expression and affects the prognosis of patients with gastric cancer

et al. 2015

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“…Furthermore, the HPV-positive patients had shorter OS and PFS compared with the HPV-negative patients, but only the levels of HGF, FIGO stage and pelvic lymph node metastasis were independent prognostic factors in the multivariate Cox analysis. Cheng et al (42) reported that GRO-1 may be a promising adverse prognostic molecular marker, and Miyake et al (43) confirmed the poor prognostic value of GRO-1 in bladder cancer. Numerous studies have demonstrated the prognostic value of sE-selectin in colorectal cancer (31,34).…”

Section: ------------------------------------------------------------mentioning

confidence: 97%

Expression of growth-regulated oncogene-1, hepatocyte growth factor, platelet-derived growth factor-AA and soluble E-selectin and their association with high-risk human papillomavirus infection in squamous cell carcinoma of the uterine cervix

Zhang

Yang

et al. 2014

Molecular Medicine Reports

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Abstract. The aim of the present study was to evaluate the clinical significance and prognostic value of growth-regulated oncogene-1 (GRO-1), hepatocyte growth factor (HGF), platelet-derived growth factor-AA (PDGF-AA), soluble E-selectin (sE-selectin) and high-risk human papillomavirus (HPV; types 16, 18/45, 31 and 33/52/58/67) infection in cervical squamous cell carcinoma (CSCC). A total of 426 cases were enrolled in the present study, of which 292 cases were patients with CSCC, 43 were patients with cervical intraepithelial neoplasia (CIN) and 91 were healthy controls. Luminex xMAP technology was used to detect the serum levels of GRO-1, HGF, PDGF-AA and sE-selectin in all cases and two-channel fluorescence quantitative polymerase chain reaction was used to determine HPV DNA in cervical scrapings from CSCC and CIN patients. The results demonstrated that the serum levels of GRO-1, HGF and sE-selectin were significantly higher in patients with CSCC compared with patients with CIN and the healthy controls (P<0.0001). Compared with the CIN patients, the HPV positive rate in the CSCC patients significantly increased (P= 0.013). The four factors were correlated with certain clinicopathological variables of CSCC patients to a certain degree (P<0.05) and the levels of HGF were closely associated with HPV infection (P= 0.039). The receiver operating characteristic curves demonstrated that HGF obtained the highest diagnostic value compared with the other three factors. Multivariate Cox regression analysis demonstrated that the serum levels of HGF (P<0.0001), FIGO stage (P<0.0001) and pelvic lymph node metastasis (P=0.001) were independent prognostic factors in patients with CSCC, while high-risk HPV infection did not show any significance in this analysis. These results demonstrated that HGF may be a useful prognostic biomarker rather than high-risk HPV types in patients with CSCC.

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“…Chemokines and chemokine receptors function in a range of physiological processes, including cancer (41,42). In GC, CXC-chemokine receptor (CXCR) CXCR4 and CXCR2 were highly expressed in cancer tissues and predicted advanced tumor stage and poorer overall survival (43,44). C-C motif chemokine receptor 7 (CCR7) is a G protein-coupled receptor preferentially expressed on naive T cells and mature dendritic cells (45).…”

Section: Lymphangiogenesis and Metastasismentioning

confidence: 99%

Molecular background of the regional lymph node metastasis of gastric cancer (Review)

Zhu

Hu²,

Wei

et al. 2018

Oncol Lett

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Abstract. Gastric cancer (GC) is one of the deadliest types of cancer in the world. Lymph node (LN) metastasis is a complex and malignant behavior of GC, involving a sequence of biological processes, including decreased adherence to adjacent cells, extracellular matrix (ECM) degradation and lymphatic channel permeation. LN metastasis is directly associated with the treatment response, local recurrence and long-term survival of patients with GC. Therefore, the molecular mechanisms of LN metastasis in GC development require further investigation. Recently, a large number of clinical studies have focused on the molecular mechanisms and biological markers of tumor invasion and metastasis. However, few articles have broadly summarized LN metastasis in GC, and the molecular mechanisms of LN metastasis are not yet fully understood. In the present review, the molecular mechanisms of LN metastasis in GC will be discussed, including the following aspects: Cell adhesion and movement, ECM degradation, new vessel formation, and molecular pattern differences between metastatic LNs and the primary tumor. This review may lead to a better understanding of LN metastasis in GC, and the identification of new diagnostic markers.

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Overexpression of CXCL1 and its receptor CXCR2 promote tumor invasion in gastric cancer

Abstract: These results provide strong evidence that CXCL1 plays an important role in gastric cancer progression and migration and suggest that CXCL1 is a promising marker for the detection and prognosis of gastric cancer.

Cited by 113 publications

References 38 publications

CXCL1 expression is correlated with Snail expression and affects the prognosis of patients with gastric cancer

CXCL1 expression is correlated with Snail expression and affects the prognosis of patients with gastric cancer

Expression of growth-regulated oncogene-1, hepatocyte growth factor, platelet-derived growth factor-AA and soluble E-selectin and their association with high-risk human papillomavirus infection in squamous cell carcinoma of the uterine cervix

Molecular background of the regional lymph node metastasis of gastric cancer (Review)

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