Overexpression of BMPER in Ovarian Cancer and the Mechanism by which It Promotes Malignant Biological Behavior in Tumor Cells

Xi, Yong; Nie, Xin; Wang, Jing; Gao, Lingling; Lin, Bei

doi:10.1155/2020/3607436

Cited by 4 publications

(5 citation statements)

References 29 publications

(30 reference statements)

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“…The suppression of BMPER inhibits the migration, invasion and proliferation of OC, and promotes apoptosis. In that study, the researchers considered that BMPER may become a potential prognostic marker and that modification of this pathway may change the role of BMPER in promoting the malignant biological behavior of ovarian cancer cells [ 90 ].…”

Section: Resultsmentioning

confidence: 99%

Ovarian Cancer and Pregnancy—A Current Problem in Perinatal Medicine: A Comprehensive Review

Dłuski

Mierzyński

Poniedziałek‐Czajkowska

et al. 2020

Cancers

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The frequency of concomitant adnexal tumors in pregnancy is reported to be at 0.15–5.7%, while ovarian cancer complicates 1 in 15,000 to 1 in 32,000 pregnancies, being the second most common gynecologic cancer diagnosed during pregnancy. The aim of this review is to discuss the problem of ovarian cancer complicating pregnancy and the current recommendations for diagnostics and treatment, with an emphasis on the risk to the fetus. A detailed analysis of the literature found in the PubMed and MEDLINE databases using the keywords “ovarian cancer”, “ovarian malignancy”, “adnexal masses”, “ovarian tumor” and “pregnancy” was performed. There were no studies on a large series of pregnant women treated for ovarian malignancies and the management has not been well established. The diagnostics and therapeutic procedures need to be individualized with respect to the histopathology of the tumor, its progression, the gestational age at the time of diagnosis and the mother’s decisions regarding pregnancy preservation. The multidisciplinary cooperation of specialists in perinatal medicine, gynecological oncology, chemotherapy, neonatology and psychology seems crucial in order to obtain the best possible maternal and neonatal outcomes.

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Section: Resultsmentioning

confidence: 99%

Ovarian Cancer and Pregnancy—A Current Problem in Perinatal Medicine: A Comprehensive Review

Dłuski

Mierzyński

Poniedziałek‐Czajkowska

et al. 2020

Cancers

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“…BMPER binds to BMP and regulates TGF-β/BMP signaling. Previous studies have linked BMPER to lung cancer and ovarian cancer [ 34 , 35 ], and it has been shown that BMPER expression is controlled by methylation at the transcriptional level. Treatment with 5-aza-dC can reduce BMPER expression in fibroblasts and mitigate invasion and migration of idiopathic pulmonary fibrosis lung fibroblasts [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have linked BMPER to lung cancer and ovarian cancer [ 34 , 35 ], and it has been shown that BMPER expression is controlled by methylation at the transcriptional level. Treatment with 5-aza-dC can reduce BMPER expression in fibroblasts and mitigate invasion and migration of idiopathic pulmonary fibrosis lung fibroblasts [ 35 ]. In our study, we observed a positive correlation between hypermethylation of cg17561435 in BMPER and the HPSM risk score, suggesting that BMPER hypermethylation may be closely associated with poor prognosis in HCC.…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of methylation-CpG prognostic signature for prognosis of hepatocellular carcinoma

He,

Guo,

Zhang

et al. 2024

Aging

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Epigenetic biomarkers help predict the prognosis of cancer patients and evaluating the clinical outcome of immunization therapy. In this study, we present a personalized gene methylation-CpG signature to enhance the accuracy of survival prediction for individuals with hepatocellular carcinoma (HCC). Utilizing RNA sequencing and methylation datasets from GEO as well as TCGA, we conducted single sample GSEA (ssGSEA), WGCNA, as well as Cox regression. Through these analyses, we identified 175 oxidative stress and immune-related genes along with 4 CpG loci that are associated with the prognosis of HCC. Subsequently, we constructed a prognostic signature for HCC utilizing these 4 CpG sites, referred to as the HCC Prognostic Signature of Methylation-CpG sites (HPSM). Further investigation revealed an enrichment of immune-related signal pathways in the HPSM-low group, which demonstrated a positive correlation with better survival among HCC patients. Moreover, the methylation of the CpG sites in HPSM was found to be closely linked to drug sensitivity. In vitro experiments tentatively confirmed that promoter methylation regulated the expression of BMPER, one of the CpG sites within HPSM. The expression of BMPER was significantly correlated with cell death in the oxidative stress pathway, and overexpression of BMPER effectively inhibited HCC cell proliferation. Consequently, our findings suggest that HPSM is an independent predictive factor and holds promise for accurately predicting the prognosis of HCC patients.

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“…Mainly adopted to treat the disease at the initial period and long term treatment, esomeprazole could be taken for the long term maintenance treatment of esophagitis and symptomatic treatment of gastroesophageal reflux disease. It could prevent the recurrence of the esophageal reflux disease efficiently, but there are few studies on the role of PPI on the hepatoma cell [10] .…”

Section: Group N Inhibition Ratio (%) 24 H 48 H 72 Hmentioning

confidence: 99%

Effect of Esomeprazole on Biological Characteristics of Hepatoma Cells by Regulating Protein Kinase B/Forkhead Box O3 Pathway

Zhang¹,

Xie²,

Sun³

2022

IJPS

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Zhang et al.: Esomeprazole on the Biological Characteristics of Hepatoma CellsTo explore the effect of esomeprazole on the biological characteristics of hepatoma cells by regulating protein kinase B/forkhead box O3 pathway. Hepatoma cell lines were cultured and subcultured and divided into model group, low dose group and high dose group. The changes of proliferation, colony formation and apoptosis of hepatoma cells in each group and the expression levels of proliferation, apoptosis related proteins and protein kinase B/forkhead box O3 pathway related proteins were detected. Esomeprazole inhibited tumor cells in a time and dose-dependent manner and the difference was statistically significant (p<0.05). With the increase of drug dose, the number of liver cancer cell colony formation decreased gradually and the difference was statistically significant (p<0.05). Esomeprazole induced apoptosis of tumor cells in a time and dose-dependent manner and the difference was statistically significant (p<0.05). Compared with the model group, the expression levels of cyclin-dependent kinase 1, cyclin-dependent kinase 2, cyclin A2 and cyclin E2 decreased with the increase of esomeprazole dose (p<0.05). Compared with the model group, the level of apoptotic protein procaspase-9 in high and low dose groups decreased significantly, while the level of cleaved caspase-9 increased in a dose-dependent manner (p<0.05). The level of protein kinase B in high dose group was lower than that in model group and low dose group, while the level of forkhead box O3 protein increased; the difference was statistically significant (p<0.05). Esomeprazole can affect the biological characteristics of tumor cells such as proliferation and apoptosis by activating protein kinase B/forkhead box O3 pathway, which provides a new method for the treatment of liver cancer.

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Overexpression of BMPER in Ovarian Cancer and the Mechanism by which It Promotes Malignant Biological Behavior in Tumor Cells

Cited by 4 publications

References 29 publications

Ovarian Cancer and Pregnancy—A Current Problem in Perinatal Medicine: A Comprehensive Review

Ovarian Cancer and Pregnancy—A Current Problem in Perinatal Medicine: A Comprehensive Review

Identification and validation of methylation-CpG prognostic signature for prognosis of hepatocellular carcinoma

Effect of Esomeprazole on Biological Characteristics of Hepatoma Cells by Regulating Protein Kinase B/Forkhead Box O3 Pathway

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