Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma

Torimura, Takuji; Ueno, Takato; Kin, Motoaki; Harada, Riko; Taniguchi, Eitaro; Nakamura, Tõru; Sakata, Ryuichiro; Hashimoto, Osamu; Sakamoto, Masaharu; Kumashiro, Ryukichi; Sata, Michio; Nakashima, Osamu; Yano, Hirohisa; Kojiro, Masamichi

doi:10.1016/j.jhep.2004.01.027

Cited by 99 publications

(84 citation statements)

References 46 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Overexpression of angiogenic factors in human cancers has been described previously, for example, for VEGF-A in lung, breast and pancreas carcinoma (Yoshiji et al, 1996;Itakura et al, 2000;Merrick et al, 2005), for FGF-2 in pancreas carcinoma and prostate cancer (Yamanaka et al, 1993;Giri et al, 1999) and for ANG-1 and ANG-2 in gastric and hepatocellular carcinoma (Torimura et al, 2004;Wang et al, 2005). However, there are also reports that disagree with the concept that tumours produce higher amounts of angiogenic factors than their normal tissue counterparts: in breast cancer tissues the expression of FGF-2 was reduced (Luqmani et al, 1992) or did not differ from the expression in normal breast tissues (Colomer et al, 1997).…”

mentioning

confidence: 79%

Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer

et al. 2009

View full text Add to dashboard Cite

BACKGROUND: Angiogenesis and lymphangiogenesis are considered to play key roles in tumour growth, progression and metastasis. However, targeting tumour angiogenesis in clinical trials showed only modest efficacy. We therefore scrutinised the concept of tumour angiogenesis and lymphangiogenesis by analysing the expression of crucial markers involved in these processes in primary breast cancer. METHODS: We analysed the expression of angiogenic, lymphangiogenic or antiangiogenic factors, their respective receptors and specific markers for endothelial and lymphendothelial cells by quantitative real-time RT-PCR in primary breast cancer and compared the expression profiles to non-cancerous, tumour-adjacent tissues and breast tissues from healthy women. RESULTS: We found decreased mRNA amounts of major angiogenic and lymphangiogenic factors in tumour compared to healthy tissues, whereas antiangiogenic factors were upregulated. Concomitantly, angiogenic and lymphangiogenic receptors were downregulated in breast tumours. This antiangiogenic, antilymphangiogenic microenvironment was even more pronounced in aggressive tumours and accompanied by reduced amounts of endothelial and lymphatic endothelial cell markers. CONCLUSION: Primary breast tumours are not a site of highly active angiogenesis and lymphangiogenesis. Selection for tumour cells that survive with minimal vascular supply may account for this observation in clinical apparent tumours.

show abstract

mentioning

confidence: 79%

Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Tumor overexpression of Ang2 was associated with vascular invasion, tumor size microvessel density level, poorly prognosis HCC [108,109] and poor differentiated tumor [110] . Preoperative presence of Ang2 in the hepatic vein was also associated with portal invasion and poor outcome in HCC resected patients [111] .…”

Section: Hepatocyte Growth Factormentioning

confidence: 93%

“…Resected specimens RT-PCR No High tumor Ang2/1 ratio Large tumor Portal vein invasion Metastasis Torimura et al [110] 59…”

Section: Tissue Biomarkersmentioning

confidence: 99%

Evaluation of antiangiogenic efficacy in advanced hepatocellular carcinoma: Biomarkers and functional imaging

Bouattour

Payancé

Wassermann

2015

WJH

View full text Add to dashboard Cite

Many years after therapeutic wilderness, sorafenib finally showed a clinical benefit in patients with advanced hepatocellular carcinoma. After the primary general enthusiasm worldwide, some disappointments emerged particularly since no new treatment could exceed or at least match sorafenib in this setting. Without these new drugs, research focused on optimi zing care of patients treated with sorafenib. One challenging research approach deals with identifying prognostic and predictive biomarkers of sorafenib in this population. The task still seems difficult; however appropriate investigations could resolve this dilemma, as observed for some malignancies where other drugs were used.

show abstract

“…Angiogenesis regulators critical to HCC metastasis has drawn a lot of attention in recent years. Vascular endothelial growth factor, 8 angiopoietin, 9 basic fibroblast growth factor, 10 platelet-derived endothelial cell growth factor, 11 and thrombospondin 12 have been reported to be angiogenic factors crucial to HCC angiogenesis.…”

mentioning

confidence: 99%

Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma

Yam

Chan

et al. 2006

Hepatology

View full text Add to dashboard Cite

Tensins are a new family of proteins that act as an important link among extracellular matrix, actin cytoskeleton, and signal transduction and have been implicated in human cancers. Tensin2 was initially identified in a search for new tensin family members that share extensive sequence homology with tensin1. Tensin2 was highly expressed in liver tissues. A recent study reported that one of the splicing variants of tensin2, variant 3, promotes cell migration. In the present study, we aimed to elucidate the role of H epatocellular carcinoma (HCC) is one of the major malignancies worldwide and the second most common fatal cancer in Asia and Hong Kong. The molecular mechanisms underlying the development, invasion, and metastasis of HCC are areas of active research. A better understanding of these areas may lead to the development of more effective prognostic markers and potential therapies for HCC. Adhesion proteins including intracellular adhesion molecule 1, 1 E-cadherin, 2 CD44 variants, 3 and extracellular matrix protein, laminin-5 4 have been reported to be biomarkers for an invasive and metastatic phenotype of HCC. Proteinases responsible for the degradation of extracellular matrix, for instance, matrix metalloproteinase, 5 urokinase-type plasminogen activator, 6 uPA receptor, and uPA inhibitor, 7 are also important factors involved in the invasiveness and metastasis of HCC. Angiogenesis regulators critical to HCC metastasis has drawn a lot of attention in recent years. Vascular endothelial growth factor, 8 angiopoietin, 9 basic fibroblast growth factor, 10 platelet-derived endothelial cell growth factor, 11 and thrombospondin 12 have been reported to be angiogenic factors crucial to HCC angiogenesis.Tensin is a new family of focal adhesion proteins that act as an important link among extracellular matrix (ECM), actin cytoskeleton, and signal transduction. 13 Recent studies have revealed that tensin proteins are also implicated in human cancers. Tensin1 is the most wellcharacterized member and best known for its activity in organizing the actin cytoskeleton and mediating signal transduction. 13 Expression of human tensin1 was shown to be down-regulated in prostate and breast cancer cell From the

show abstract

Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma

Cited by 99 publications

References 46 publications

Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer

Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer

Evaluation of antiangiogenic efficacy in advanced hepatocellular carcinoma: Biomarkers and functional imaging

Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma

Contact Info

Product

Resources

About