Overexpression of amplified in breast cancer 1 (<i>AIB1</i>) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C‐X‐C motif chemokine receptor 4

He, Liru; Deng, Huimin; Liu, Shiliang; Chen, Jiewei; Li, Binkui; Wang, Chenyuan; Wang, Xin; Jiang, Yiguo; Ma, Ning‐Fang; Liu, Mengzhong; Xie, Dan

doi:10.1186/s40880-018-0320-1

Cited by 7 publications

(5 citation statements)

References 48 publications

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“…4,5 In spite of tremendous therapeutic progress, the prognosis of lung patients with adenocarcinoma is still very poor. 6 In addition, metastasis is the main reason for the high death rate of patients with NSCLC after tumor resection. 7 Thus, it is imperative to investigate the latent molecular mechanism of lung adenocarcinoma invasion and metastasis to discover better therapeutic strategies and reduce the mortality of patients with lung adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

“…NSCLC constitutes approximately 80% of lung cancer cases, and lung adenocarcinoma is the main histologic subtype of NSCLC, which accounts for 60% of NSCLC . In spite of tremendous therapeutic progress, the prognosis of lung patients with adenocarcinoma is still very poor . In addition, metastasis is the main reason for the high death rate of patients with NSCLC after tumor resection .…”

Section: Introductionmentioning

confidence: 99%

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LncRNA TTN‐AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR‐4677‐3p/ZEB1 axis

Zhong

Wang

et al. 2019

J of Cellular Biochemistry

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Lung adenocarcinoma is the most prevalent type of lung cancer with a high incidence and mortality worldwide. Metastasis is the major cause of high death rate in lung cancer and the potential mechanism of lung adenocarcinoma metastasis remains indistinct. Emerging investigations have demonstrated that long noncoding RNA is a kind of non–protein coding RNA and plays a critical role in cancer progression and metastasis. TTN antisense RNA 1 (TTN‐AS1) has been reported to promote cell growth and metastasis in cancer. However, the function of TTN‐AS1 in lung adenocarcinoma is still to be illustrated. In this study, we observed that TTN‐AS1 was upregulated in tissues and cells of lung adenocarcinoma and associated with poor overall survival. TTN‐AS1 promoted cell proliferation, migration, invasion, and epithelial‐mesenchymal transition in lung cancer. TTN‐AS1 directly bound with miR‐4677‐3p and negatively regulated miR‐4677‐3p. MiR‐4677‐3p rescued the inhibitive impacts of TTN‐AS1 knockdown on lung adenocarcinoma. Furthermore, zinc finger E‐box binding homeobox 1 (ZEB1) was the target of miR‐4677‐3p, and TTN‐AS1 modulated ZEB1 by competing for miR‐4677‐3p. TTN‐AS1 drove the invasion and migration of lung adenocarcinoma cells by targeting the miR‐4677‐3p/ZEB1 axis. To sum up, our study offers insights into the mechanism of TTN‐AS1 in lung adenocarcinoma metastasis and targeting the TTN‐AS1/miR‐4677‐3p/ZEB1 axis may be the potential innovate therapeutic strategy for the patients with lung adenocarcinoma.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

LncRNA TTN‐AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR‐4677‐3p/ZEB1 axis

Zhong

Wang

et al. 2019

J of Cellular Biochemistry

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“…The correlation between lung cancer and breast cancer has been elucidated by some established theories, as most of the literature, including that of Lin et al and other ongoing in vitro studies, have attributed the association to inherited susceptibility [ 1 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. After searching and reviewing some of the research literature, we supposed that air pollution, or more specifically, long-term exposure to fine particulate matter (PM2.5), may be another risk factor that leads to the carcinogenesis of the two cancers.…”

Section: Discussionmentioning

confidence: 99%

Association between Breast Cancer and Second Primary Lung Cancer among the Female Population in Taiwan: A Nationwide Population-Based Cohort Study

Lin

Yeh

Lin

et al. 2022

Cancers

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Purpose: A special association between breast cancer and second primary lung cancer in Taiwanese women has been discovered not only in clinical practice, but also in a large population-based study. We hereby investigate the association between breast cancer and second primary lung cancer in Taiwanese women. Methods: This study was conducted from the National Health Insurance Research Database (NHIRD) from Taiwan National Health Insurance (NHI). Patients older than 18 years old and hospitalized with a first diagnosis of breast cancer during 2000 to 2012 were enrolled in the breast cancer group. Patients who were cancer free were frequency-matched with the breast cancer group by age (every five-year span) and index year. The ratio of breast cancer group to non-breast cancer group was 1:4. The event as the outcome in this study was lung cancer. The comorbidities viewed as important confounding factors included coronary artery disease, stroke, hypertension, diabetes, chronic obstructive pulmonary disease, hyperlipidemia, tuberculosis, chronic kidney disease, and chronic liver disease and cirrhosis. We estimated the hazard ratios (HRs), adjusted hazard ratios (aHRs), and 95% confidence intervals (CIs) for risk of lung cancer in the breast cancer group and non-breast cancer group using Cox proportional hazard models. Sensitivity analysis was also done using propensity score matching. All of the statistical analyses were performed using SAS statistical software, version 9.4 (SAS Institute Inc., Cary, NC). Results: There were 94,451 breast cancer patients in the breast cancer group and 377,804 patients in the non-breast cancer group in this study. After being stratified by age, urbanization level, and comorbidities, the patients with breast cancer had a significantly higher risk of lung cancer compared with the patients without breast cancer, particularly for those who aged between 20 and 49 years (aHR = 2.10, 95% CI = 1.71–2.58), 50 and 64 years (aHR = 1.35, 95% CI = 1.15–1.58), and those without any comorbidities (aHR = 1.92, 95% CI = 1.64–2.23). Conclusion: Patients with breast cancer had a significantly higher risk of developing second primary lung cancer compared with patients without breast cancer, particularly in younger groups and in those without any comorbidities. The special association may be attributed to some potential risk factors such as genetic susceptibility and long-term exposure to PM2.5, and is supposed to increase public awareness. Further studies are necessary given the fact that inherited genotypes, different subtypes of breast cancer and lung cancer, and other unrecognized etiologies may play vital roles in both cancers’ development.

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“…C-X-C motif chemokine receptor 4 (CXCR4) plays an important role in the cell proliferation and metastasis of lung adenocarcinoma. SRC-3 overexpression could increase CXCR4 expression to promote metastasis [ 149 ]. In addition, the atypical MAPK ERK3 signaling induced SRC-3 phosphorylation at S857 through the interaction of SRC-3 and ERK3.…”

Section: Implication Of Src-3 In Cancermentioning

confidence: 99%

SRC-3, a Steroid Receptor Coactivator: Implication in Cancer

Li¹,

Deng²,

Chen³

2021

IJMS

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Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functions, it also acts as an oncogene to promote multiple aspects of cancer. This review updates the important progress of SRC-3 in carcinogenesis and summarizes its mode of action, which provides clues for cancer therapy.

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Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C‐X‐C motif chemokine receptor 4

Cited by 7 publications

References 48 publications

LncRNA TTN‐AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR‐4677‐3p/ZEB1 axis

LncRNA TTN‐AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR‐4677‐3p/ZEB1 axis

Association between Breast Cancer and Second Primary Lung Cancer among the Female Population in Taiwan: A Nationwide Population-Based Cohort Study

SRC-3, a Steroid Receptor Coactivator: Implication in Cancer

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