Overexpression of a Long Non-Coding RNA BC037916 is Associated with Pancreatic Tumorigenesis and Poor Prognosis

Chen, Gang; Xu, Litao; Ye, Guanxiong; Lin, Jiahao; Meng, Zhiqiang; Shen, Yehua

doi:10.2147/ott.s282350

Cited by 2 publications

(2 citation statements)

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“…Twist is a transcription factor that regulates the process of EMT process. Increased expression of BC037916 was also found to increase the activation of the STAT3 pathway in pancreatic cancer cells 403 . lncRNAs can promote cancer stem‐like cell properties by activating the STAT3 pathway in human cancers.…”

Section: Ncrnas and Stat3 Regulation In Gastrointestinal Cancersmentioning

confidence: 91%

“…Increased expression of BC037916 was also found to increase the activation of the STAT3 pathway in pancreatic cancer cells. 403 lncRNAs can promote cancer stem-like cell properties by activating the STAT3 pathway in human cancers. LncRNA HOTAIR, which is overexpressed in pancreatic cancer cells over its normal counterpart, sponges miR-34a and activates JAK2/STAT3 axis to promote cancer stem-like cell features.…”

Section: Pancreatic Cancermentioning

confidence: 99%

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Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

Ashrafizadeh

Mohan

Rangappa

et al. 2023

Medicinal Research Reviews

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Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic transcription factor that promotes the transcription of genes associated with proliferation, antiapoptosis, survival, and metastasis. STAT3 is overactivated in many human malignancies including GI tumors which accelerates tumor progression, metastasis, and drug resistance. Research in recent years demonstrated that noncoding RNAs (ncRNAs) play a major role in the regulation of many signaling pathways including the STAT3 pathway. The major types of endogenous ncRNAs that are being extensively studied in oncology are microRNAs, long noncoding RNAs, and circular RNAs. These ncRNAs can either be tumor‐promoters or tumor‐suppressors and each one of them imparts their activity via different mechanisms. The STAT3 pathway is also tightly modulated by ncRNAs. In this article, we have elaborated on the tumor‐promoting role of STAT3 signaling in GI tumors. Subsequently, we have comprehensively discussed the oncogenic as well as tumor suppressor functions and mechanism of action of ncRNAs that are known to modulate STAT3 signaling in GI cancers.

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Section: Ncrnas and Stat3 Regulation In Gastrointestinal Cancersmentioning

confidence: 91%

Section: Pancreatic Cancermentioning

confidence: 99%