Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients

Kim, Yeon Joo; Kim, Na Young; Lee, Min Kyung; Choi, Hyo Jin; Baek, Han Joo; Nam, Chang-Hoon

doi:10.3858/emm.2010.42.5.030

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…Significant difference was shown in the expression level of VH2 gene to HuPo (1.31 ± 1.03, 1.41 ± 1.29, and 7.70 ± 6.53, respectively; p < 0.0001; Figure 1). These results were consistent with those of the previous study 8 .…”

Section: Restoration Of Overexpressed Variable Heavy Chain 2 Transcrisupporting

confidence: 94%

“…Several studies have investigated the VH gene usage in various autoimmune diseases, including systemic lupus erythematosus 4 , myasthenia gravis 5 , rheumatoid arthritis (RA) 6 , Sjögren syndrome 7 , and AS 8,9 compared to healthy controls. A previous study of VH gene usage in patients with AS reported overexpression and rearrangement of the VH2 gene 8 . However, it has not been clear whether this phenomenon was specific for AS or is a general feature in other rheumatic diseases.…”

Section: Restoration Of Overexpressed Variable Heavy Chain 2 Transcrimentioning

confidence: 92%

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Restoration of Overexpressed Variable Heavy Chain 2 Transcripts with Tumor Necrosis Factor Inhibitors in Ankylosing Spondylitis

Sheen

Kim²,

Lee³

et al. 2014

J Rheumatol

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Section: Restoration Of Overexpressed Variable Heavy Chain 2 Transcrisupporting

confidence: 94%

Section: Restoration Of Overexpressed Variable Heavy Chain 2 Transcrimentioning

confidence: 92%

Restoration of Overexpressed Variable Heavy Chain 2 Transcripts with Tumor Necrosis Factor Inhibitors in Ankylosing Spondylitis

Sheen

Kim²,

Lee³

et al. 2014

J Rheumatol

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“…1 C). V2-5 is also found in Ankylosing Spondylitis (AS) [ 62 ] and Alzheimer’s disease (AD) [ 63 , 64 ]. AD was also found to be associated with mouse V8-12 as human V2-5 [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

“…Human HIV-2 virus are V2-5 positive [ 61 ] and accumulated macrophage and hepcidin increases with iron decrease, thus maintenance of viral set-point [ 159 , 160 ]. Ankylosing spondylitis (AS) with most V H 2 (dominant V2-5) [ 62 ] are the neutrophils progression, and Alzheimer’s disease in brain (AD) found in V2-5 are with macrophage polarization subsets, most in bacteria [ 161 ]. Both AS and AD showed hepcidin + plays with an important role [ 162 , 163 ].…”

Section: Resultsmentioning

confidence: 99%

B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice

Hayakawa,

Zhou,

Shinton

2024

Immun Ageing

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Human old aged unmutated chronic lymphocytic leukemia U-CLL are the TCL1+ZAP70+CD5+ B cells. Since CD5 makes the BCR signaling tolerance, ZAP70 increased in U-CLL not only TCL1+ alone. In mice, TCL1 (TCL1A) is the negative from neonate to old aged, as TC–. VH8-12/Vk21-5 is the anti-thymocyte/Thy-1 autoreactive ATA B cell. When ATA μκTg generation in mice, ATA B cells are the neonate generated CD5+ B cells in B-1, and in the middle age, CD5+ can be down or continuously CD5+, then, old aged CLL/lymphoma generation with increased CD11b in TC–ZAP70–CD5– or TC–ZAP70+CD5+. In this old aged TC–ATA B microarray analysis showed most similar to human CLL and U-CLL, and TC–ZAP70+CD5+ showed certain higher present as U-CLL. Original neonate ATA B cells showed with several genes down or further increase in old aged tumor, and old aged T-bet+CD11c+, CTNNB1hi, HMGBhi, CXCR4hi, DPP4hi and decreased miR181b. These old aged increased genes and down miR181b are similar to human CLL. Also, in old age ATA B cell tumor, high CD38++CD44++, increased Ki67+ AID+, and decreased CD180– miR15Olow are similar to U-CLL. In this old aged ATA B, increased TLR7,9 and Wnt10b. TC+Tg generated with ATAμκTg mice occurred middle age tumor as TC+ZAP70–CD5+ or TC+ZAP70+CD5+, with high NF-kB1, TLR4,6 and Wnt5b,6 without increased CD11b. Since neonatal state to age with TC+Tg continuously, middle age CLL/lymphoma generation is not similar to old aged generated, however, some increased in TC+ZAP70+ are similar to the old age TC– ATA B tumor. Then, TC– ATA B old age tumor showed some difference to human CLL. ATA B cells showed CD11b+CD22++, CD24 down, and hepcidin Hamp2++ with iron down. This mouse V8-12 similar to human V2-5, and V2-5 showed several cancers with macrophages/neutrophils generated hepcidin+ ironlow or some showed hepcidin– iron+ with tumor, and mouse V8-12 with different Vk19-17 generate MZ B cells strongly increased macrophage++ in old aged and generated intestine/colon tumor. Conclusion, neonate generated TC–ATA B1 cells in old aged tumor generation are CD11b+ in the leukemia CLL together with lymphoma cancer with hepcidin-related Hamp2++ in B-1 cell generation to control iron.

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“…This is due to the non‐random use of certain V gene segments that gives different immune responses towards infections among individuals whereby some individuals exhibit stronger resistance toward certain infections and vice versa. Analyses of the use of immunoglobulin V genes in a number of studies have revealed a preferential antibody V gene repertoire for patients with ankylosing spondylitis, systemic lupus erythematosus, chronic lymphocytic leukaemia and other diseases.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of IgA V_H3 gene usage in healthy TST⁻ and TST⁺ population exposed to tuberculosis: deep sequencing analysis

et al. 2015

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SummaryThe acquired immune response against tuberculosis is commonly associated with T-cell responses with little known about the role of B cells or antibodies. There have been suggestions that B cells and humoral immunity can modulate the immune response to Mycobacterium tuberculosis. However, the mechanisms involving B-cell responses in M. tuberculosis are not fully understood, in particular the antibody gene preferences. We hypothesized that a preferential use of V genes can be seen associated with resistance to infection mainly in the IgA isotype, which is of prominent importance for infection by pathogens via the mucosal route. We studied healthy individuals with long-term exposure to tuberculosis, infected (TST + ) and uninfected TST À ) with M. tuberculosis. From a total of 22 V genes analysed, the TST À population preferred the V H 3-23 and Vj1 genes. The V H 3-23 genes were subsequently subjected to 454 amplicon sequencing. The TST À population showed a higher frequency of the D3-10 segment compared with the D3-22 segment for the TST + population. The J segment usage pattern was similar for both populations with J4 segment being used the most. A preferential pairing of J4 segments to D3-3 was seen for the TST À population.The antibodyome difference between both populations suggests a preference for antibodies with V H 3-23, D3-3, J H 4 gene usage by the TST À population that could be associated with resistance to infection with M. tuberculosis.

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Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients

Cited by 8 publications

References 30 publications

Restoration of Overexpressed Variable Heavy Chain 2 Transcripts with Tumor Necrosis Factor Inhibitors in Ankylosing Spondylitis

Restoration of Overexpressed Variable Heavy Chain 2 Transcripts with Tumor Necrosis Factor Inhibitors in Ankylosing Spondylitis

B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice

Comparative study of IgA V_H3 gene usage in healthy TST⁻ and TST⁺ population exposed to tuberculosis: deep sequencing analysis

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Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients

Cited by 8 publications

References 30 publications

Restoration of Overexpressed Variable Heavy Chain 2 Transcripts with Tumor Necrosis Factor Inhibitors in Ankylosing Spondylitis

Restoration of Overexpressed Variable Heavy Chain 2 Transcripts with Tumor Necrosis Factor Inhibitors in Ankylosing Spondylitis

B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice

Comparative study of IgA VH3 gene usage in healthy TST− and TST+ population exposed to tuberculosis: deep sequencing analysis

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Comparative study of IgA V_H3 gene usage in healthy TST⁻ and TST⁺ population exposed to tuberculosis: deep sequencing analysis