Overexpression and Cytocidal Activity of Parasporin-1 from Bacillus thuringiensis against Human Cancer Cell Lines

Assaeedi, Abdulrahman; Osman, Gamal

doi:10.4172/1948-5948.1000368

Cited by 2 publications

(2 citation statements)

References 40 publications

(39 reference statements)

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“…Control procedures are normally established on the use of chemicals, insect pesticides have been widely utilized for house fly control (van Emden and Peakall, 1996). These chemical pesticides hold prospective dangers for both the environment as well as human health and continuously lead to the development of resistance to most used insecticides (Asaeedi et al, 2017).Various pesticides used to control flies showed harmful effects on non-objective organisms, involving those that are natural control agents, such as predators and parasitoids (Scott et al, 1991). To diminish harmful effects on health, environment and to prevent pollution of the ecosystem, research for new highly efficient alternative strategies for pest control such as biopesticides has increased (Rodrigues et al, 1988;Zimmer et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Musca Domestica: A Vector of Pathogenic Microorganisms and Biocontrol Approaches

Al-Nasser¹,

El-Ghwas²,

Al-Sheikhy³

2021

GJSFR

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House fly “Musca domestica” Linnaeus is a common insect widely distributed all over the world and is one of the domestic insect pests found associated with human and animal. Due to their habits and habitats, house flies are able to transmit several pathogenic microorganisms to man such as: bacteria, fungi and virus. House flies are not just annoying human and animal, but they also have been known as vectors of infectious microorganisms either mechanically or biologically. Chemical insecticides have been used for many years and have been known as the most effective approach in house fly management but due to their side effects on the environment and the increasing development of pest resistance to each new chemical, studies tended to explore new alternative methods in pest control. Biological methods including different predators, parasites, entomopathogenic micro-organisms and botanical extracts showed in the last years a practical and effective ecofriendly method to control insect pests including house fly and at the same time safe on human and animal.

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Section: Introductionmentioning

confidence: 99%

Musca Domestica: A Vector of Pathogenic Microorganisms and Biocontrol Approaches

Al-Nasser¹,

El-Ghwas²,

Al-Sheikhy³

2021

GJSFR

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“…The results were not satisfactory. It was noted that the control programs adopted only on chemical pesticides led to natural imbalance and the appearance of immunity in many of the target pests [3][4][5] , as well as pollution of the entire ecosystem, which led the world to limit the use of chemical pesticides in the control of insects in general and Musca Domestica in particular and the search for new high efficiency means to be introduced in the control system without disturbing the natural balance or pollution of the environment 6 . The most important of these was the use of highly specialized bactericides in the eradication of medical pests 7 .…”

Section: Introductionmentioning

confidence: 99%

The Effect of Bacillus thuringiensis israelensis (Bti) as a Microbial Control Agent against Musca domestica in Makkah Region

Bahareth¹,

Alsahhaf²,

Saleh³

et al. 2018

J Pure Appl Microbiol

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Bacillus thuringiensis (Bt) is a gram-positive spore forming bacteria. It forms a spore in an adverse condition i.e. when nutrients are limited. Bt produces protein crystals in the cytoplasm of the mother cell during sporulation. The protein crystals are insoluble protoxins, when synthesized the ä-endotoxins consist of two multigenic families, Cry and Cyt. Cry proteins are toxic to different insect orders. They are toxic to Lepidoptera, Coleoptera, Hymenoptera, Diptera and also to nematodes.The use of manufactured high toxic pesticides with their harm environmental effect led to search for non-traditional means of control. Musca Domestica plays an important role in the transmission of many pathogens such as cholera, typhoid, trachoma, diarrhea, tuberculosis, salmonella and intestinal sedimentation.The results recorded illustrated the efficiency of Bti bacteria at concentrations (0.5, 1.0, 1.5 and 20%) against the second instar larvae of the domestic fly M. domestica. The results of this study show that the different concentrations of Bti Clearly indicate the percentage of larvae where they increase directly and gradually by increasing the concentration (16, 52 and 80%) of the concentrations used respectively. The results recorded potential effects of the laboratory biocide on the second larval life span of Mucosa domestica. The life span of the mature phase, the number of eggs per female (fertility) and the percentage of hatching, and the number of mutilated individuals were recorded. The results shown that the bacterial pesticide causes a significant decrease in larval life span compared with the control group (10.36±0.027) since the minimum life span is 2.45±0.251 days at concentration of 0.5%, maximum life span is (8.68± 0.158) Days at concentration of 20%.

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Overexpression and Cytocidal Activity of Parasporin-1 from Bacillus thuringiensis against Human Cancer Cell Lines

Cited by 2 publications

References 40 publications

Musca Domestica: A Vector of Pathogenic Microorganisms and Biocontrol Approaches

Musca Domestica: A Vector of Pathogenic Microorganisms and Biocontrol Approaches

The Effect of Bacillus thuringiensis israelensis (Bti) as a Microbial Control Agent against Musca domestica in Makkah Region

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