Overexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer

Kim, Kwang S.; Kim, Jong-Tae; Lee, Seon-Jin; Kang, Min Sung; Choe, In Seong; Kang, Yun Hee; Kim, Seon‐Young; Yeom, Young Il; Lee, Young-Ha; Kim, Joo Heon; Kim, Kyo Hyun; Kim, Chang Nam; Kim, Jong Wan; Nam, Myoung-Soo; Lee, Hee Gu

doi:10.1016/j.cca.2012.09.003

Cited by 52 publications

(40 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The oxygen concentration decreases along the GI tract, and this fact could explain why CEACAM6 is expressed at basal levels in colonic mucosa. In addition, hypoxic stress, which is frequently observed in colorectal tumours, could be responsible for the upregulation of CEACAM6 in colon cancer tissues because we observed that hypoxia induces CEACAM6 expression in a HIF-1-dependent manner 32 33. Other mechanisms involved in the regulation of CEACAM6 gene have previously been reported in IEC.…”

Section: Discussionsupporting

confidence: 60%

Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associatedEscherichia colicolonisation

Denizot

Agus

Uhrhammer

et al. 2014

Gut

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 60%

Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associatedEscherichia colicolonisation

Denizot

Agus

Uhrhammer

et al. 2014

Gut

View full text Add to dashboard Cite

show abstract

“…Again, over-expression of CEACAM6 was associated with poor OS (p<0.001) and a reduced recurrence-free survival (RFS) (p<0.001). Interestingly, through the use of invasive assays and CEACAM6 knockdown models via small interfering RNA (siRNA), CRC cells were found to have diminished invasiveness (35%), whereas over-expression resulted in increased invasiveness through the extracellular matrix (ECM) [27]. CEACAM6 knockdown results in an increased E-cadherin promoter activity which suggests that CEACAM6 serves as a crucial regulator of metastatic potential.…”

Section: Ceacam6 Biology Expression and Prognostic Implications In mentioning

confidence: 99%

Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies

Johnson

Mahadevan²

2015

CCAND

View full text Add to dashboard Cite

Background: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is a member of the CEA family of cell adhesion proteins that belong to the immunoglobulin superfamily. CEACAM6 is normally expressed on the surface of myeloid (CD66c) and epithelial surfaces. Stiochiomertic expression of members of the CEA family (CEACAM1, 5, 6, 7) on epithelia maintains normal tissue architecture through homo-and hetero-philic interactions. Dysregulated over-expression of CEACAM6 is oncogenic, is associated with anoikis resistance and an invasive phenotype mediated by excessive TGFβ, AKT, FAK and SRC signaling in human malignancies. Methods: Extensive literature review through PubMed was conducted to identify relevant preclinical and clinical research publications regarding CEACAM6 over the last decade and was summarized in this manuscript. Results: CEACAM5 and 6 are over-expressed in nearly 70% of epithelial malignancies including colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDA), hepatobiliary, gastric, breast, non-small cell lung and head/neck cancers. Importantly, CEACAM6 is a poor prognostic marker in CRC, while its expression correlates with tumor stage, metastasis and post-operative survival in PDA. CEACAM6 appears to be an immune checkpoint suppressor in hematologic malignancies including acute lymphoblastic leukemia and multiple myeloma. Several therapeutic monoclonal antibodies or antibody fragments targeting CEACAM6 have been designed and developed as a targeted therapy for human malignancies. A Llama antibody targeting CEACAM6 is being evaluated in early phase clinical trials. Conclusion: This review focuses on the role of CEACAM6 in the pathogenesis and signaling of the malignant phenotype in solid and hematologic malignancies and highlights its potential as a therapeutic target for anti-cancer therapy.

show abstract

“…In contrast, over-expression of CEACAM5 and CEACAM6 is detected in nearly 70% of solid tumors, including cancers of the gastrointestinal tract, breast, lung, and female reproductive system, and is associated with greater migration, invasion, and metastasis in vitro [4][5][6][7][8][9]. Expression of CEACAM6 is suggested to be an independent prognostic factor in colorectal cancer [8,9], and its level is associated with tumor stage, metastasis, and postoperative survival of patients with pancreatic cancer [10]. However, few studies have thus far been focused on CEA CAM6 expression in GC and the resulting data are still largely controversial.…”

Section: Introductionmentioning

confidence: 99%

CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer

Zhang¹,

Zang²,

Li³

et al. 2014

ABBS

View full text Add to dashboard Cite

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) shows increased expression in a wide variety of human cancers, and its over-expression is associated with enhanced migration, invasion, and in vivo metastasis. Here, we reported that CEACAM6 was up-regulated in gastric cancer (GC) cell lines and tumor tissues. Overexpression of CEACAM6 in MKN-45 and SGC-7901 GC cells promoted migration and invasion in vitro and metastasis in athymic mice, whereas migration and invasion of MKN-28 and SNU-16 GC cells were suppressed by knockdown of CEACAM6. We also observed that steroid receptor coactivator (C-SRC) phosphorylation was increased when CEACAM6 was over-expressed in SGC-7901 cells. Taken together, these results suggested that CEACAM6 functions as an oncoprotein in GC and may be an important metastatic biomarker and therapeutic target.

show abstract

Overexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer

Cited by 52 publications

References 28 publications

Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associatedEscherichia colicolonisation

Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associatedEscherichia colicolonisation

Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies

CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer

Contact Info

Product

Resources

About