volume 8, issue 6, P1236-1248 2016
DOI: 10.18632/aging.100980
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Li-Si Zeng, Xian-Zi Yang, Yue-Feng Wen, Shi-Juan Mai, Meng-He Wang, Mei-Yin Zhang, X.F. Steven Zheng, Hui-Yun Wang

Abstract: Histone deacetylases (HDACs) mediate histone deacetylation, leading to transcriptional repression, which is involved in many diseases, including age-related tissue degeneration, heart failure and cancer. In this study, we were aimed to investigate the expression, clinical significance and biological function of HDAC4 in esophageal carcinoma (EC). We found that HDAC4 mRNA and protein are overexpressed in esophageal squamous cell carcinoma (ESCC) tissues and cell lines. HDAC4 overexpression is associated with hi…

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