Overeating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM study

Lope, Virginia; Martín, Miguel; Castelló, Adela; Ruı́z, Amparo; Casas, Ana; Baena-Cañada, José Manuel; Antolín, Silvia; Ramos-Vázquez, Manuel; García-Sáenz, José Ángel; Muñoz, Montserrat; Lluch, Ana; Juan-Ferré, Ana de; Jara, Carlos; Sánchez‐Rovira, Pedro; Antón, Antonio; Chacón, José Ignacio; Arcusa, Àngels; Jimeno, M. A.; Bezares, Susana; Vioque, Jesús; Carrasco, Eva; Pérez‐Gómez, Beatriz; Pollán, Marina

doi:10.1038/s41598-019-39346-4

Cited by 29 publications

(22 citation statements)

References 34 publications

(52 reference statements)

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“…Patient information was anonymized and de-identified prior to analysis. Further details regarding the study design have been previously published [ 27 , 28 ].…”

Section: Methodsmentioning

confidence: 99%

Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype

et al. 2020

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This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30–0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49–0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48–0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20–2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12–2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14–2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45–2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.

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“…Patient information was anonymized and de-identified prior to analysis. Further details regarding the study design have been previously published [ 27 , 28 ].…”

Section: Methodsmentioning

confidence: 99%

Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype

et al. 2020

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“…These changes result in a positive energy balance—the state in which energy intake exceeds energy expenditure—which, over time, can lead to obesity. Several studies have shown that reducing caloric intake and increasing physical activity may be protective against both pre- and post-menopausal breast cancer (38, 39). As such, targeting modifiable risk factors of obesity such as diet and physical activity is one strategy to reduce breast cancer risk and improve survival.…”

Section: Epidemiology Of Obesity and Breast Cancer Risk According To mentioning

confidence: 99%

The Many Faces of Obesity and Its Influence on Breast Cancer Risk

2019

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Obesity is associated with increased risk of breast and other cancers. However, the complexity of the underlying mechanisms, together with the interplay of diet and physical activity-contributing to energy balance-and the role of adipose tissue, pose challenges to our understanding of the basis of this increased risk. Epidemiologic studies have documented a higher obesity prevalence in US black women compared to white women. Elucidation of the contribution of potential biological differences among racially distinct groups to their differences in breast cancer (BC) risk and mortality have been topics of considerable interest in recent years. The racial and ethnic variation in body fat distribution may account for at least part of the differences in breast cancer rates in these populations. Yet, while black women exhibit higher rates of obesity compared to white women, this does not translate directly into higher rates of BC. In fact, overall, BC in black women occurs with a lower incidence than BC in white women. Obesity is a known risk factor for postmenopausal breast cancer, and growing evidence suggests that abdominal obesity, also known as central obesity, may increase risk for triple negative breast cancer, which is more common in premenopausal women. The positive association of postmenopausal BC risk and specifically estrogen receptor (ER)-positive BC, is presumably due largely to accumulation of estrogen in the adipose tissue of the breast and other tissues. Of the two main types of adipose tissue-subcutaneous and visceral-visceral adipocytes are more active metabolically. Such adipose tissue harbors multiple molecular entities that promote carcinogenesis: endocrine molecules/hormones, immunologic factors, inflammatory cytokines, metabolic alterations, and other components of the microenvironment. Expression of these culpable entities is largely regulated by epigenetic mechanisms. The interrelationship between these entities and drivers of epigenetic alteration are critical to the regulation of pathways connecting obesity and cancer risk. Initiatives to counteract the carcinogenic effects of obesity have primarily involved modulation of energy balance by diet. However, targeting of specific molecular abnormalities characterizing adiposity offers an alternative approach to preventing cancer. Our goal in this review is to first discuss the major mechanisms contributing to the obesity-breast cancer link. We will also consider race, specifically black/white differences, as they relate to the association of obesity with breast cancer risk. Then we will enumerate strategies targeting these mechanisms to reduce BC risk, in large part by way of dietary interventions with potential to mitigate the cancer-promoting components of adiposity.

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“…All this evidence leads researchers to investigate the epigenetic modifications and beneficial effects induced by dietary restriction and physical exercise in women and BC patients to assess the reduction of BC risk, the decrease of BC recurrence, and the therapeutic potential of food administration [5,36,37]. However, no convincing data have been generated on this topic and no epigenetic biomarkers predictive of the therapeutic efficacy and patient prognosis have been identified as yet.…”

Section: Introductionmentioning

confidence: 99%

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

Falzone

Grimaldi

Celentano

et al. 2020

Cancers

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Background: Several studies have shown that healthy lifestyles prevent the risk of breast cancer (BC) and are associated with better prognosis. It was hypothesized that lifestyle strategies induce microRNA (miRNA) modulation that, in turn, may lead to important epigenetic modifications. The identification of miRNAs associated with BC, diet, and physical activity may give further insights into the role played by lifestyle interventions and their efficacy for BC patients. To predict which miRNAs may be modulated by diet and physical activity in BC patients, the analyses of different miRNA expression datasets were performed. Methods: The GEO DataSets database was used to select miRNA expression datasets related to BC patients, dietary interventions, and physical exercise. Further bioinformatic approaches were used to establish the value of selected miRNAs in BC development and prognosis. Results: The analysis of datasets allowed the selection of modulated miRNAs associated with BC development, diet, and physical exercise. Seven miRNAs were also associated with the overall survival of BC patients. Conclusions: The identified miRNAs may play a role in the development of BC and may have a prognostic value in patients treated with integrative interventions including diet and physical activity. Validation of such modulated miRNAs on BC patients undergoing lifestyle strategies will be mandatory.

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Overeating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM study

Cited by 29 publications

References 34 publications

Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype

Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype

The Many Faces of Obesity and Its Influence on Breast Cancer Risk

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

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