Overcoming Treatment Resistance in Medulloblastoma: Underlying Mechanisms and Potential Strategies
Hasan Slika,
Aanya Shahani,
Riddhpreet Wahi
et al.
Abstract:Medulloblastoma is the most frequently encountered malignant brain tumor in the pediatric population. The standard of care currently consists of surgical resection, craniospinal irradiation, and multi-agent chemotherapy. However, despite this combination of multiple aggressive modalities, recurrence of the disease remains a substantial concern, and treatment resistance is a rising issue. The development of this resistance results from the interplay of a myriad of anatomical properties, cellular processes, mole… Show more
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