Overcoming the tumor biological barrier: a multistage drug delivery strategy for DDR1-mediated resistant colorectal cancer therapy
Jun Yan,
Guangman Cui,
Shaohui Deng
et al.
Abstract:Chemotherapy resistance remains a significant challenge in the treatment of colorectal cancer (CRC). The roles of discoidin domain receptor 1 (DDR1) in mediating tumor-collagen interactions and promoting cancer progression have been extensively studied. However, the specific mechanisms of DDR1 contribute to matrix-mediated drug resistance (MMDR) remain poorly understood. In this study, we elucidated a novel mechanism in which the interactions between tumor cells and collagen lead to promotion of drug efflux an… Show more
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