Overcoming skin barriers through advanced transdermal drug delivery approaches

Phatale, Vivek; Vaiphei, Klaudi K.; Jha, Shikha; Patil, D. S.; Agrawal, Mukta; Alexander, Amit

doi:10.1016/j.jconrel.2022.09.025

Cited by 157 publications

(107 citation statements)

References 157 publications

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“…However, many researchers still view the intercellular pathway as holding enormous delivery potential that remains underexplored using conventional vesicular systems. Thus, driven by the need to further enhance the skin penetration efficiency of conventional vesicles (i.e., classical liposomes), which rarely provide satisfactory transdermal effects, new classes of ultradeformable vesicles have been designed by structural and chemical modifications of liposomes [ 54 , 108 , 109 ]. These relatively new vesicular systems, due to their smaller size and, more importantly, their ability to press through intercellular lipid bilayers present in the stratum corneum, exhibit superior delivery of cargo drugs to deeper skin layers (dermis), from which they can be absorbed into the bloodstream [ 110 , 111 ].…”

Section: Lipid Nanosystems Utilized In Skin Deliverymentioning

confidence: 99%

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

et al. 2023

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Skin delivery is an exciting and challenging field. It is a promising approach for effective drug delivery due to its ease of administration, ease of handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, and many other advantages. The main associated challenge, however, is low skin permeability. The skin is a healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in skin delivery (both topical and transdermal) depend on overcoming the challenges associated with drug molecule permeation and skin irritation. These limitations can be overcome by employing new approaches such as lipid nanosystems. Due to their advantages (such as easy scaling, low cost, and remarkable stability) these systems have attracted interest from the scientific community. However, for a successful formulation, several factors including particle size, surface charge, components, etc. have to be understood and controlled. This review provided a brief overview of the structure of the skin as well as the different pathways of nanoparticle penetration. In addition, the main factors influencing the penetration of nanoparticles have been highlighted. Applications of lipid nanosystems for dermal and transdermal delivery, as well as regulatory aspects, were critically discussed.

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Section: Lipid Nanosystems Utilized In Skin Deliverymentioning

confidence: 99%

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

et al. 2023

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“…Skin also acts as a reservoir, which enables the diffusion of the penetrated drugs from skin continuously for a longer period and presents an opportunity of lower frequency of administration ( Qu et al, 2022 ). As the stratum corneum (SC) layer of the skin is the capital barrier which limits the penetration of most drugs, many approaches have been adopted to disrupt the SC layer and increase skin permeability, including physical enhancers (iontophoresis, electroporation, sonophoresis, and microneedles), chemical enhancers (alcohol and peptide), and delivery vehicles (spherical nucleic acid and lipoplexes) ( Ita 2017 ; Phatale et al, 2022 ; Qu et al, 2022 ). It is reported that transdermal drug delivery approaches enable topical drug delivery to the periarticular tissues of TMJs, which offer a painless and convenient platform to treat TMJOA-associated conditions ( Figure 2 and Table 2 ).…”

Section: Transdermal Drug Delivery Systemsmentioning

confidence: 99%

Drug delivery systems for treatment of temporomandibular joint osteoarthritis

et al. 2022

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The number of people suffering from temporomandibular joint osteoarthritis (TMJOA) has been increasing. TMJOA cause joint noise, pain on TMJ and/or masticatory muscles, and restricted mandibular movement, which disturb eating, laughing and conversation, and impose serious lifestyle impediments. Chondrocyte apoptosis, extracellular matrix degradation, synovitis, and subchondral bone remodeling are the main pathological features of TMJOA. Various drug delivery systems are developed to controlled release at specific activation sites with high bioactivity and inhibit rapid dilution to enable long-term therapeutic response, which present great potential for the treatment of TMJOA. This review focuses on recently developed drug delivery systems by different administration in the TMJOA treatment, and summarizes their effects, duration, safety, and limitations, which would pave the way for development of TMJOA therapy.

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“…Optimization of transdermal patch will be done on the basis of % of cumulative drug release , flux and folding endurance of patches [17] .…”

Section: Optimizationmentioning

confidence: 99%

Design, Development and Evaluation of Eucalyptol Transdermal Patch for Anti-Diabetic Activity

Perada¹

2022

Journal of Pharmaceutical Negative Results

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For almost two hundred years, diabetes mellitus has been a major health problem worldwide. While there has been progress in our knowledge of its pathophysiology and treatment, the therapeutic choices available today are woefully inadequate. The goal of transdermal medication delivery systems is to provide therapeutically effective doses of a medicine via the skin. The medicine is released at a steady, regulated pace thanks to the design of these devices. As a result, it is well suited for the management of long-term conditions like diabetes. Thus, the risks and inconvenient nature of the oral and parenteral routes are avoided. The purpose of this study is to develop and test eucalyptol transdermal patches for the treatment of diabetes. Drug distribution from different polymer-based transdermal patches might be enhanced by using oleic acid as a penetration enhancer. Matrix-style transdermal patches, composed of PVP K30, HPMC K100, and solvent, were created utilizing solvent casting procedures. By using Fourier transform infrared spectroscopy, researchers were able to examine the drug's and polymers' physicochemical compatibility. No evidence of physical or chemical incompatibility between the medication and the polymers was found. The patches also underwent a battery of physical tests in addition to the in-vivo research. The patches with the polymers, that is, PVP K30, HPMC K100, and oleic acid as the penetration enhancer, were regarded the best formulations for the transdermal distribution of eucalyptol based on the findings obtained from the physical assessment, ex vivo investigations, and in-vivo studies.

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Overcoming skin barriers through advanced transdermal drug delivery approaches

Cited by 157 publications

References 157 publications

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Drug delivery systems for treatment of temporomandibular joint osteoarthritis

Design, Development and Evaluation of Eucalyptol Transdermal Patch for Anti-Diabetic Activity

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