Overcoming Resistance in Prostate Cancer Therapy Using a DZ-Simvastatin Conjugate
Yan Ou,
Gina Chia-Yi Chu,
Ji Lyu
et al.
Abstract:Prostate
cancer (PC), particularly its metastatic castration-resistant
form (mCRPC), is a leading cause of cancer-related deaths among men
in the Western world. Traditional systemic treatments, including hormonal
therapy and chemotherapy, offer limited effectiveness due to tumors’
inherent resistance to these therapies. Moreover, they often come
with significant side effects. We have developed a delivery method
using a tumor-cell-specific heptamethine carbocyanine dye (DZ) designed
to transport therapeutic age… Show more
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