Overcoming phenotypic switching: targeting protein-protein interactions in cancer
Christos Ladias,
Pavlos Papakotoulas,
Maria Papaioannou
et al.
Abstract:Alternative protein-protein interactions (PPIs) arising from mutations or post-translational modifications (PTMs), termed phenotypic switching (PS), are critical for the transmission of alternative pathogenic signals and are particularly significant in cancer. In recent years, PPIs have emerged as promising targets for rational drug design, primarily because their high specificity facilitates targeting of disease-related signaling pathways. However, obstacles exist at the molecular level that arise from the pr… Show more
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