Overcoming Barriers: Evidence-Based Strategies to Increase Enrollment of Underrepresented Populations in Cancer Therapeutic Clinical Trials—a Narrative Review

Vuong, Iris; Wright, J. Skelly; Nolan, Margaret; Eggen, Amanda; Bailey, Erin; Strickland, Rick; Traynor, Anne M.; Downs, Tracy M.

doi:10.1007/s13187-019-01650-y

Cited by 46 publications

(36 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…69 Despite growing proportion and rising childhood cancer incidence in racial and ethnic minorities in the United States, 70 trust in medical research/system, language discordance, trial designs, and travel challenges. [72][73][74][75][76][77][78] Evidence suggests that physicians are less likely to discuss trial enrollment with African Americans due to concerns of being perceived as distrustful. 79 Providers' negative attitudes have also been found to influence encounters with minorities, 80 leading providers to perceive them as not ideal candidates.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta‐analytic evaluation of psychosocial interventions in parents of children with cancer with an exploratory focus on minority outcomes

Eche

Yusufov

Isibor

et al. 2021

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Parents of children with cancer are prone to psychosocial distress, yet little is known about intervention response among diverse parents. Our systematic review and metaanalysis evaluated the efficacy of psychosocial interventions on anxiety and depression among parents of children with cancer and explored race and/or ethnicity differences in the efficacy of these interventions. Twenty articles met inclusion. The aggregate effect size on anxiety (−0.01, 95% CI: −0.95, 0.93, p = .97) and depression (−0.56, 95% CI: −1.65, 0.54, p = .32) showed micro to medium effects, with larger negative effect sizes indicating that anxiety and depression scores after treatment were lower for parents in intervention group as compared to control group. Neither aggregate effect size was statistically significantly different from zero. Due to underrepresentation of minorities, we could not perform subgroup or moderator analyses. Several efficacious psychosocial interventions were found to reduce parental anxiety. Future studies to examine psychosocial interventions in minority parents are warranted. K E Y W O R D S efficacy of psychosocial interventions, meta-analysis, parents of children with cancer, systematic review

show abstract

Section: Discussionmentioning

confidence: 99%

A systematic review and meta‐analytic evaluation of psychosocial interventions in parents of children with cancer with an exploratory focus on minority outcomes

Eche

Yusufov

Isibor

et al. 2021

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…Cultural and linguistic adaptations and building community partnerships should be considered in both recruitment and intervention delivery strategies. 40 We learned that education about yoga may increase interest and that it is possible to recruit older veterans to yoga class. Nevertheless, in study 2, our rate of full participation was low, with only about 1 in 10 participating.…”

Section: Discussionmentioning

confidence: 99%

Enhancing Access to Yoga for Older Male Veterans After Cancer: Examining Beliefs About Yoga

Auguste¹

2021

Federal Practitioner

View full text Add to dashboard Cite

“…Numerous barriers to patient participation in research studies have been described, including practical impediments that limit access, lack of knowledge, financial concerns, and both patient and provider attitudinal barriers [ [5] , [6] , [7] ]. Recommendations for overcoming these barriers have been predominantly directed at physicians [ [7] , [8] , [9] , [10] , [11] ], patients [ [12] , [13] , [14] ], and communities [ [15] , [16] , [17] ]. Unfortunately, intervention studies to date have not been shown to result in measurable improvement in clinical trial participation at a national level.…”

Section: Introductionmentioning

confidence: 99%

Randomized trial of a web-based nurse education intervention to increase discussion of clinical trials

Margevicius

Daly

Schluchter

et al. 2021

Contemporary Clinical Trials Communications

View full text Add to dashboard Cite

Background Clinical trials are a critical source of evidence for oncology care, yet very few patients participate. Among healthcare providers, nurses spend the most time with cancer patients and are the most highly trusted professionals. We developed and evaluated an educational program for oncology nurses targeting knowledge, attitudes, self-efficacy and perceived norms to facilitate discussion about clinical trials and support patient decision making. Methods A nationwide sample of oncology nurses were randomly assigned to receive general clinical trials education delivered as text (attention control) vs. tailored video vignettes (intervention) in a web-based continuing education program. Participants completed a baseline assessment and follow up assessments immediately after the educational program and three months later. The primary outcome was intention to discuss clinical trials with patients. Secondary outcomes were knowledge and attitudes about clinical trials, self-efficacy, and perceived norms. Results 1393 nurses enrolled and completed the educational program and post-intervention assessment (720 control, 673 video). Both text education and tailored video education increased intention to discuss clinical trials with patients, with a greater effect in the video group (p < .0001). Likewise, knowledge, attitudes, perceived behavioral control, and perceived norms were all improved with education in both groups, and the magnitude of benefit was greater (p < .001) for the video group in all outcomes except knowledge. Conclusion A one-time online educational program for oncology nurses improves knowledge, attitudes, self-efficacy and intention to engage patients in discussions about clinical trials. A tailored video format was associated with a greater effect than standard text only material.

show abstract

Overcoming Barriers: Evidence-Based Strategies to Increase Enrollment of Underrepresented Populations in Cancer Therapeutic Clinical Trials—a Narrative Review

Cited by 46 publications

References 27 publications

A systematic review and meta‐analytic evaluation of psychosocial interventions in parents of children with cancer with an exploratory focus on minority outcomes

A systematic review and meta‐analytic evaluation of psychosocial interventions in parents of children with cancer with an exploratory focus on minority outcomes

Enhancing Access to Yoga for Older Male Veterans After Cancer: Examining Beliefs About Yoga

Randomized trial of a web-based nurse education intervention to increase discussion of clinical trials

Contact Info

Product

Resources

About