Overcome side identification in PPOP by making orifices on both layers

Li, Wei; Nie, Song; Tang, Xin; Peng, Bo; Tian, Lei; Pan, Wei-San

doi:10.1016/j.ijpharm.2008.12.006

Cited by 13 publications

(3 citation statements)

References 12 publications

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“…Furthermore, it was apparent that the amount of the drug released increased with an increase in the amount of PVP K-30 in the coating because of the increasing number of drug delivery orifices (Figure 3). The results obtained are in good agreement with findings of many researchers [14][15][16][17][18][19][20] but in contrast with the finding of Garg et al 21 The linearity of ketoprofen release profiles decreases as the amount of PVP increases in the coating, indicating increased diffusional contribution resulting from leaching out of more pore former from the coating that gives rise to increased number of drug delivery orifices. CA microporous membrane-coating containing PVP (in combination of plasticizers) as a pore former was reported in the past, but contrarily at a higher optimal weight gain of 15% (w/w) 19 .…”

Section: Resultssupporting

confidence: 90%

Design of a 24-hour controlled porosity osmotic pump system containing PVP: formulation variables

Yakubu

Peh

Tan

2009

Drug Development and Industrial Pharmacy

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Section: Resultssupporting

confidence: 90%

Design of a 24-hour controlled porosity osmotic pump system containing PVP: formulation variables

Yakubu

Peh

Tan

2009

Drug Development and Industrial Pharmacy

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“…Nghiên cứu đã sử dụng PEO N10 có TLPT thấp (100.000 Da) trong lớp dược chất và PEO 303 có TLPT cao (7000.000 Da) trong lớp đẩy. Lựa chọn này là khá tương đồng với nghiên cứu của các tác giả S. Missaghi [6], Z. Zhang [8], C. Wu [9], V. Patel [10]. Thành phần màng bao, trong đó tỷ lệ tá dược hóa dẻo và độ dày màng bao là các thông số quan trọng để kiểm soát tốc độ thấm nước vào viên qua đó ảnh hưởng đến giải phóng thuốc, khi tăng tỷ lệ tá dược hóa dẻo hoặc giảm khối lượng màng bao dẫn đến tốc tăng tốc độ giải phóng thuốc và ngược lại.…”

Section: Bàn Luậnunclassified

Preparation of Nifedipine Push-Pull Osmotic Pump Tablets

Trung¹,

Dao²,

Hải³

et al. 2020

MPS

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This study aims to investigate the influence of the formulation factors on the drug release kinetics, thereby selecting the compositions of extended-release nifedipine tablet based on the similarity coefficient f2 obtained when compared with Adalat LA tablet. The formulation factors such as: molecular weight of the polyethylene oxide (PEO) and osmotic agent amount in drug layer and push layer, semi permeable membrane thickness (estimated by coating weight gain), orifice size, type of plasticizers and ratios of coating polymer to plasticizer in semipermeable membrane were evaluated. It was found that developed tablets were able to deliver nifedipine in an approximate zero-order manner up to 20 hours and drug release profile of developed tablets was similar to that from Adalat LA tablets. The developed tablet contained: PEO N10, PEO 303 in drug layer and push layer, respectively; percentages of osmotic agent in drug layer and push layer were 10% and 30%, respectively; weight gain of semipermeable coating was 12%; and orifice size was 0.8 mm. Keywords Nifedipine, GPKD, push-pull osmotic pump, PEO, Tlag. References [1] Vietnamese National Drug Formulary Council, Nifedipine, Vietnamese National Drug Formulary, 2nd edition, Medical Publising House, Hanoi, 2018, pp. 1056-1058 (in Vietnamese).[2] A. Nokhodchi, M.N. Momin, J. Shokri, et al., Factors affecting the release of nifedipine from a swellable elementary osmotic pump, Drug Delivery, 15 (1) (2008) 43-48. https://doi.org/10.1080/10717540701829028[3] R.K. Verma, D.M. Krishna, S. Garg, Formulation aspects in the development of osmotically controlled oral drug delivery systems, Journal of controlled release 79 (1-3) (2002) 7-27. https://doi.org/10.1016/s0168-3659(01)00550-8.[4] The United States Pharmacopeial Convention, Nifedipine Extended-Release Tablets, The United States Pharmacopeia, 41st edition, United Book Press, Baltimore, 2018, pp. 2938 - 2944.[5] V. Malaterre, J. Ogorka, N. Loggia, et al., Approach to design push–pull osmotic pumps, International Journal of Pharmaceutics 376 (1–2) (2009) 56-62. http://dx.doi.org/10.1016/j.ijpharm.2009.04.015.[6] S. Missaghi, P. Patel P, Farrell T. P., et al., Investigation of critical core formulation and process parameters for osmotic pump oral drug delivery, AAPS PharmSciTech 15 (1) (2014) 149-160. http://doi.org/10.1208/s12249-013-0040-4.[7] V. Malaterre, H. Metz, J. Ogorka , et al., Benchtop-magnetic resonance imaging (BT-MRI) characterization of push-pull osmotic controlled release systems, J Control Release 133 (1) (2009) 31-36. http://doi.org/10.1016/j.jconrel.2008.09.007.[8] Z. Zhang, W. Li, S. Nie, et al., Overcome side identification in PPOP by making orifices on both layers, International journal of pharmaceutics 371 (1-2) (2009) 1-7. http://dx.doi.org/10.1016/j.ijpharm.2008.12.006[9] C. Wu, Z. Zhao, Y. Zhao, et al., Preparation of a push–pull osmotic pump of felodipine solubilized by mesoporous silica nanoparticles with a core–shell structure, International Journal of Pharmaceutics,475 (1-2) (2014) 298 - 305 . http://dx.doi.org/10.1016/j.ijpharm.2014.08.033.[10] V. Patel, A. Chudasama, M. Nivsarkar, et al., Push-pull osmotic pump for zero order delivery of lithium carbonate: Development and in vitro characterization, Pharmaceutical development and technology, 17 (3) (2012) 375-382. http://doi.org/10.3109/10837450.2010.542577.[11] C.N. Patra, S. Swain, J. Sruti, et al., Osmotic drug delivery systems: Basics and design approaches, Recent Patents on Drug Delivery & Formulation 7(2) (2013) 1 - 12. http://doi.org/10.2174/1872211311307020007.

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“…Some of the rules were static, which were saved in the database; while the others were dynamic, which were planted in the inference engine, such as procedures. Details of rules could refer to the literature (Zhang et al, 2009). …”

Section: The Construction Of Rule Basementioning

confidence: 99%