Overall treatment time in advanced cervical carcinomas: A critical parameter in treatment outcome

Girinsky, T.; Rey, Annie; Roche, B.; Haie, C.; Gerbaulet, A.; Randrianarivello, Harizo; Chassagne, D.

doi:10.1016/0360-3016(93)90522-w

Cited by 261 publications

(101 citation statements)

References 15 publications

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“…Using three statistical methods of analysis in 830 patients, they observed loss of local control of approximately 1% per day when treatment lasted over 30 days, most evident in stage III and IV patients. Girinsky et al (1993) also reported decreased rates of local control and survival when the treatment period was longer than 52 days. By multiple regression analysis, they observed loss of 1.1% local control per day when the treatment period was prolonged from 52 days to more than 62 days.…”

Section: Discussionmentioning

confidence: 98%

“…First, the overall treatment period is short. Several studies have shown that overall treatment time is a significant prognostic factor for patients with cervical cancer treated with radiation therapy alone (Fyles et al, 1992;Girinsky et al, 1993;Lanciano et al, 1993;Perez et al, 1995; Radiation therapy alone for carcinoma of the uterine cervix T Ota et al Delaloye et al, 1996). Fyles et al (1992) reported the influence of treatment duration on local control.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

et al. 2007

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The objective of this retrospective study was to determine the survival rate, incidence of late complications, and incidence of second cancers when radiation therapy alone is used for carcinoma of the uterine cervix. Between 1971 and 1995, 1495 patients with squamous cell carcinoma of the uterine cervix (stages I -IV) were treated with radiation therapy alone in our hospital. Radiation therapy consisted of a combination of high-dose-rate intracavitary brachytherapy and external beam radiotherapy. The cumulative 5-year survival rates for stages Ib, II, and III/IVa carcinoma were 93.5, 77.0, and 60.3%, respectively, and the 10-year survival rates were 90.9, 74.5, and 56.1%, respectively. Local control rates for stages Ib, II, and III/IVa carcinoma were 92.0, 79.4 and 64.2%, respectively. Eighty-two (5.5%) patients suffered grade III/IV or V (fatal) complications. A second cancer developed in 13 (0.87%) patients. Second cancers were observed most frequently in the rectum (five cases), colon (three cases), and uterine body (two cases). Long-term follow-up data revealed that our method of radiation therapy alone for locally advanced carcinoma of the uterine cervix is effective, with low incidences of late complications and second cancers.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

et al. 2007

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“…It is generally recognized that radiation therapy given over extended time interval is associated with reduced survival. [24][25][26].…”

Section: Radiation Therapy Durationmentioning

confidence: 99%

Younger age as a bad prognostic factor in patients with carcinoma of the cervix

Jf¹,

Pampallona²,

Coucke³

et al. 1996

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: To verify the influence of age on the prognosis of cervix carcinoma. Study design: Five hundred and sixty eight patients treated for a FIGO stage IB-IVA with radical irradiation in the Centre Hospitalier Universitaire Vaudois of Lausanne were subdivided according to the following age categories: _<45, 46-60, 61-69 and > 70 years. Taking the 46-60 years age group as the reference, the hazard ratios (HR) of death and corresponding 95% confidence intervals (95% CI) were estimated by means of a Cox multivariate analysis. Results: The 5-year survival rates were, respectively, 57%, 67%, 60% and 45%. For the youngest women the risk of death was significantly increased (HR = 2.00, 95% CI [1.32-3.00]) and was even more accentuated in advanced stages. Conclusion: Age under 45 years is a bad prognostic factor in carcinoma of the cervix.

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“…Studies of the increase in tumor control dose with increasing treatment time suggest that after a variable lag period, surviving tumor clonogens regenerate rapidly during fractionated radiation therapy to the extent that each additional day of treatment requires *0.6 Gy, on average, to offset clonogenic cell regeneration, again suggesting a clonogenic cell doubling time of 3.5-5 days [5]. Many trials have conclusively proven overall treatment time to be a major determinant in the outcome in cervix cancer [6][7][8][9][10][11]. The usual recommendation is to complete treatment by 8 weeks (56 days) [12].…”

Section: Discussionmentioning

confidence: 99%

Pure Accelerated Radiation Versus Concomitant Chemoradiation in Selected Cases of Locally Advanced Carcinoma Cervix: A Prospective Study

Roy

Choudhury

Pal

et al. 2012

J Obstet Gynecol India

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Objective This non-randomized study was conducted to assess and compare the response and safety of true accelerated radiation alone to concomitant chemoradiation in locally advanced squamous cell carcinoma of the uterine cervix. Methods Sixty patients with locally advanced squamous cell carcinoma of the uterine cervix, FIGO Stages (2009) IB2-IIIB were non-randomized to receive six fractions per week of external beam radiation (EBRT) (will be henceforth referred to as Arm A or Study arm or pure accelerated radiation arm) and five fractions per week of EBRT and chemotherapy with inj cisplatin 40 mg/m 2 i.v. every

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Overall treatment time in advanced cervical carcinomas: A critical parameter in treatment outcome

Cited by 261 publications

References 15 publications

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

Younger age as a bad prognostic factor in patients with carcinoma of the cervix

Pure Accelerated Radiation Versus Concomitant Chemoradiation in Selected Cases of Locally Advanced Carcinoma Cervix: A Prospective Study

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