Overall survival is improved in mucinous adenocarcinoma of the colon

Hogan, John; Burke, John P.; Samaha, Georges; Condon, Eoghan; Waldron, David; Faul, P.; Coffey, J. Calvin

doi:10.1007/s00384-013-1826-2

Cited by 38 publications

(31 citation statements)

References 30 publications

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“…this group has recently demonstrated this potential caveat. 6 a retrospective comparative analysis comparing mucinous and nonmucinous adenocarcinoma of the colon alone demonstrated an independent association between mucinous and improved overall survival contrary to the findings of studies combining CC and RC. Consequently, the role of lVi+ in oncological outcomes is yet to be separately established in CC and RC, 23,24 OBJECTIVE this study aims to separately evaluate the role of lVi+ in CC and RC with respect to overall survival (os), disease-free survival (Dfs), and locoregional and systemic recurrence.…”

contrasting

confidence: 63%

“…[1][2][3][4][5] however, 20% of node-negative patients develop disease recurrence, hence, the importance of additional prognostic parameters in distinguishing high-and low-risk patients. [6][7][8][9] lymphovascular invasion (lVi) (characterized by the extension of tumor cells into lymphatic and/or blood vessels) is used as an adjunct to tnm staging in stage ii CRC. lymphovascular invasion positivity (lVi+) is a critical prognostic indicator and, as such, is documented in over 90% of histopathology reports.…”

mentioning

confidence: 99%

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Lymphovascular Invasion

Hogan

Chang

Duff

et al. 2015

Diseases of the Colon &Amp; Rectum

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contrasting

confidence: 63%

mentioning

confidence: 99%

Lymphovascular Invasion

Hogan

Chang

Duff

et al. 2015

Diseases of the Colon &Amp; Rectum

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“…However, some studies have reported a lower survival rate in patients with a MCC [152224]. Surprisingly, Hogan et al [28] showed an improved survival in patients with a mucinous carcinoma of the colon. These discrepancies may reflect heterogeneity in the population of patients, lack of stratification by stage, exclusion of rectal primary tumors in some studies, and different numbers of patients accrued.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Mucinous Histologic Subtype on Oncologic Outcomes in Patients With Colorectal Cancer

et al. 2017

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PurposeMucinous adenocarcinomas account for about 10% of all colorectal cancers. This study aimed to investigate the prognostic impact of mucinous histologic subtype on oncologic outcomes in patients with colorectal cancer.MethodsThis retrospective study was performed at two large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of patients with colorectal cancer who were treated and followed up between 2000 and 2013.ResultsTotally, 144 of 1,268 patients with a colorectal adenocarcinoma (11.4%) had mucinous histologic subtype. Statistically significant results found in this research are as follows: Mucinous histologic subtype tended to present in younger patients and to have larger tumor size, higher histologic grade, higher node stage, larger number of positive nodes, and higher rate of perineural invasion compared to nonmucinous histologic subtype. On the univariate analysis, mucinous subtype was a prognostic factor for disease-free and overall survival. On the multivariate analysis, primary tumor location, node stage and lymphatic-vascular invasion were independent prognostic factors for the local control rate. Rectal tumor location, higher disease stage, tumor grade II, and presence of lymphatic-vascular invasion had negative influences on disease-free survival, as did rectal tumor location, higher disease stage and presence of lymphatic-vascular invasion on overall survival.ConclusionMucinous histologic subtype was associated with some adverse pathologic features in patients with colorectal cancer; however, it was not an independent prognostic factor for oncologic outcome.

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“…An analysis from the National Cancer Database showed inferior OS in MA of the rectum but not of the colon [9]. Interestingly, Hogan et al reported an improved survival in patients with MA [25].…”

Section: Discussionmentioning

confidence: 99%

Factors associated with short recurrence-free survival in completely resected colon cancer

Alnimer

Ghamrawi

Aburahma

et al. 2017

Journal of Community Hospital Internal Medicine Perspectives

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Background: Several factors could affect disease recurrence in surgically resected colon cancer. While the role of certain factors such as cancer stage and grade is well established, the role of other factors (e.g., histological subtypes) is yet to be determined. Objective:Therefore, we conducted a study to evaluate the impact of several factors in recurrence-free survival (RFS) in patients who were disease free following surgical resection of the colon cancer. Design/Methods: Data were collected for patients with Stage I–III colon cancer who underwent complete surgical resection of the tumor between January 2010 and December 2015 in our institution. A total of 90 subjects met the inclusion criteria and were included in the study. The following factors were collected at the time of surgical resection of the colonic tumor: patient’s age, gender, colon cancer stage, grade and histological subtype, body mass index, hemoglobin A1c, and smoking history. Results: A total of 28 patients (31%) developed recurrence and had a mean follow-up time of 19.8 months (range: 2–54.4 months). Median RFS was 54.4 months with a 5-year RFS of 49%. Advanced colonic cancer stage and mucinous histological subtype were associated with shorter RFS with an HR of 2.37, 95% CI = 1.38–4.06, and 95% CI = 1.02–5.90, respectively. Current smokers or those who quit less than 15 years earlier tended to have worse RFS with an HR of 2.47, 95% CI = 0.98–6.27. Conclusion: Advanced colon cancer stage and mucinous histological subtype are independent risk factors for cancer recurrence and shorter RFS in completely resected colonic tumor.

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Overall survival is improved in mucinous adenocarcinoma of the colon

Abstract: Histopathological evidence of mucinous adenocarcinoma in colon cancer is associated with improved outcomes.

Cited by 38 publications

References 30 publications

Lymphovascular Invasion

Lymphovascular Invasion

Prognostic Significance of Mucinous Histologic Subtype on Oncologic Outcomes in Patients With Colorectal Cancer

Factors associated with short recurrence-free survival in completely resected colon cancer

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