Overall Impairment of Quality of Life in Japanese Patients with Hidradenitis Suppurativa: Comparison with National Standard

Abstract

is missing (Short communication)

Real‐world safety and effectiveness of adalimumab in patients with hidradenitis suppurativa: A 52‐week analysis of a postmarketing surveillance study in Japan

“…12 and 52 weeks were substantially lower in this study than in the HARMONY study. Health-related QOL is considerably affected by bodily pain, 8 therefore the greater reduction in skin pain observed in this study compared with that observed in the HARMONY study 15 (NRS 1.7 vs. 2.69 at 52 weeks) may have contributed to the difference observed in DLQI scores. Furthermore, given that the baseline DLQI score in this study was similar to that reported by a recent Japanese multicenter questionnaire-based study (8.5 vs. 9.9), 8 the difference in DLQI scores between the current study and the HARMONY study may also be due to the difference in ethnicity (Japanese vs. White).…”

“…This is similar to the results observed in the HARMONY study, 15 which reported an approximately 50% reduction in DLQI from baseline (16.9) to 52 weeks (8.6), although the mean DLQI scores at baseline and at 12 and 52 weeks were substantially lower in this study than in the HARMONY study. Health‐related QOL is considerably affected by bodily pain, 8 therefore the greater reduction in skin pain observed in this study compared with that observed in the HARMONY study 15 (NRS 1.7 vs. 2.69 at 52 weeks) may have contributed to the difference observed in DLQI scores. Furthermore, given that the baseline DLQI score in this study was similar to that reported by a recent Japanese multicenter questionnaire‐based study (8.5 vs. 9.9), 8 the difference in DLQI scores between the current study and the HARMONY study may also be due to the difference in ethnicity (Japanese vs. White).…”

“…The global prevalence of HS, which is estimated to be 0.00033%–4.1%, 2 varies markedly among geographic regions and ethnicity 3 . HS is associated with painful inflammatory nodules, abscesses, sinus tract formations, and scarring, which can have a substantial impact on the patient's mental health, social functioning, and quality of life (QOL) 4–8 . The pathogenesis of HS is not fully understood, making disease management challenging.…”

“…which can have a substantial impact on the patient's mental health, social functioning, and quality of life (QOL). [4][5][6][7][8] The pathogenesis of HS is not fully understood, making disease management challenging. However, it is thought to be multifactorial, with genetic, immunological, behavioral, and endocrine factors interplaying in the development of HS.…”

The psychosocial burden of hidradenitis suppurativa in Singapore

“…A Japanese questionnaire based study similarly found positive correlation between disease severity (PGA, modified Sartorius score, and Hurley stage) and DLQI. 19 No correlation was reported between disease severity and the components of social functioning, role-emotional or mental health of the Short Form-36 health survey version 2 QoL scale was performed in this study.…”