Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based study in 9 countries

Cardoso, Rafael; Guo, Feng; Heisser, Thomas; Schutter, Harlinde De; Damme, Nancy Van; Nilbert, Mef; Christensen, Jane; Bouvier, Anne-Marie; Bouvier, Véronique; Launoy, Guy; Woronoff, Anne‐Sophie; Cariou, Mélanie; Robaszkiewicz, Michel; Delafosse, Patricia; Poncet, F.; Walsh, Paul; Senore, Carlo; Rosso, Stefano; Lemmens, Valery; Elferink, M.A.G.; Tomšič, Sonja; Žagar, Tina; Marques, Arantza Lopez de Munain; Marcos‐Gragera, Rafael; Puigdemont, Montse; Galcerán, Jaume; Carulla, Marià; Sánchez-Gil, Antonia; Chirlaque, María‐Dolores; Hoffmeister, Michael; Brenner, Hermann

doi:10.1016/j.lanepe.2022.100458

Cited by 36 publications

(33 citation statements)

References 24 publications

(31 reference statements)

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“…and higher stage-specific survival. 20 In the United States, the proporof distant metastasis CRC stage in 2013-2019 was 23%. 21 While TNM stage I CRC are treated by surgery alone, either endoscopically, laparoscopically or by abdominal resection, with 5-year survival reaching 99%, 5,22,23 the treatment for stages II-III relies on surgery followed by adjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Stage at diagnosis of colorectal cancer in the Middle East and Northern Africa: A population‐based cancer registry study

Znaor,

Eser,

Bendahhou

et al. 2024

Intl Journal of Cancer

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Colorectal cancer (CRC) is the 2nd most common cancer and 3rd most common cause of death in the Middle East and Northern Africa (MENA) region. We aimed to explore CRC stage at diagnosis data from population‐based cancer registries in MENA countries. In 2021, we launched a Global Initiative for Cancer Registry Development (GICR) survey on staging practices and breast and CRC stage distributions in MENA. According to the survey results, population‐based data on TNM stage for CRC were available from six registries in five countries (Kuwait, Morocco, Oman, Türkiye, UAE). The proportion of cases with unknown TNM stage ranged from 14% in Oman to 47% in Casablanca, Morocco. The distribution of CRC cases with known stage showed TNM stage IV proportions of 26–45%, while the proportions of stage I cancers were lowest in Morocco (≤7%), and highest (19%) in Izmir, Türkiye. Summary extent of disease data was available from six additional registries and four additional countries (Algeria, Bahrain, Iraq, Qatar). In summary, the proportions of CRC diagnosed with distant metastases in Oman, Bahrain and UAE were lower than other MENA countries in our study, but higher than in European and the US populations. Harmonising the use of staging systems and focusing stage data collection efforts on major cancers, such as CRC, is needed to monitor and evaluate progress in CRC control in the region.

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Section: Discussionmentioning

confidence: 99%

Stage at diagnosis of colorectal cancer in the Middle East and Northern Africa: A population‐based cancer registry study

Znaor,

Eser,

Bendahhou

et al. 2024

Intl Journal of Cancer

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“…The comparison of attained age and survival times between deceased and surviving persons at follow-up end assumes that both groups have similar survival times. This assumption can be incorrect if there are substantial advances in therapy or if, because of the introduction of screening, cancers are detected earlier over the course of follow-up ( 16 , 17 ). Large improvements in survival raise the probability that patients who are still alive due to the new therapy or whose cancer has been detected early through screening will be misclassified as missed deaths.…”

Section: Discussionmentioning

confidence: 99%

Detection of missed deaths in cancer registry data to reduce bias in long-term survival estimation

Dahm

Barnes²,

Kraywinkel³

2023

Front. Oncol.

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BackgroundPopulation-based cancer survival estimates can provide insight into the real-world impacts of healthcare interventions and preventive services. However, estimation of survival rates obtained from population-based cancer registries can be biased due to missed incidence or incomplete vital status data. Long-term survival estimates in particular are prone to overestimation, since the proportion of deaths that are missed, for example through unregistered emigration, increases with follow-up time. This also applies to registry-based long-term prevalence estimates. The aim of this report is to introduce a method to detect missed deaths within cancer registry data such that long-term survival of cancer patients does not exceed survival in the general population.MethodsWe analyzed data from 15 German epidemiologic cancer registries covering the years 1970-2016 and from Surveillance, Epidemiology, and End Results (SEER)-18 registries covering 1975-2015. The method is based on comparing survival times until exit (death or follow-up end) and ages at exit between deceased patients and surviving patients, stratified by diagnosis group, sex, age group and stage. Deceased patients with both follow-up time and age at exit in the highest percentile were regarded as outliers and used to fit a logistic regression. The regression was then used to classify each surviving patient as a survivor or a missed death. The procedure was repeated for lower percentile thresholds regarding deceased persons until long-term survival rates no longer exceeded the survival rates in the general population.ResultsFor the German cancer registry data, 0.9% of total deaths were classified as having been missed. Excluding these missed deaths reduced 20-year relative survival estimates for all cancers combined from 140% to 51%. For the whites in SEER data, classified missed deaths amounted to 0.02% of total deaths, resulting in 0.4 percent points lower 20-year relative survival rate for all cancers combined.ConclusionThe method described here classified a relatively small proportion of missed deaths yet reduced long-term survival estimates to more plausible levels. The effects of missed deaths should be considered when calculating long-term survival or prevalence estimates.

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“…Systematic collection of data through synoptic reports can also build national-level registries to study regional and temporal trends. Thus far, colorectal registries in North America are fractionated, and lack the power of long-standing registries that exist in European countries [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Interval Colorectal Cancer: A Canadian Retrospective Population-Level Analysis from Newfoundland and Labrador

et al. 2022

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Interval colorectal cancers (I-CRCs) arise during the interval time period between scheduled colonoscopies. Predicting which patients are at risk of I-CRCs remains an elusive undertaking, but evidence would suggest that most I-CRCs arise from lesions missed on index endoscopy. The procedural factors that lead to missed lesions are numerous and lack consensus in the literature. In Canada, the province of Newfoundland and Labrador has the highest incidence of CRCs. In this study our aim was to examine I-CRCs (3–60 months after last colonoscopy) in NL through a population-level analysis covering 67% of the province from 2001–2018. We estimated the I-CRC rate to be up to 9.3%. Median age of I-CRC diagnosis was 67.1 years with an interval time of 2.9 years. About 57% of these tumors occurred proximal to the splenic flexure, with 53% presenting as local disease. No temporal differences were observed in interval time or tumor distribution. On univariate and multivariable logistical regression, risk of right-sided I-CRC did not correlate to the index colonoscopy indication, bowel preparation quality, size of largest polyp removed, colonoscopy completion rate, or stage at presentation. Improvements in synoptic reporting utilization and national registries are needed to identity risk factors and reduce I-CRC frequency.

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Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based study in 9 countries

Cited by 36 publications

References 24 publications

Stage at diagnosis of colorectal cancer in the Middle East and Northern Africa: A population‐based cancer registry study

Stage at diagnosis of colorectal cancer in the Middle East and Northern Africa: A population‐based cancer registry study

Detection of missed deaths in cancer registry data to reduce bias in long-term survival estimation

Characteristics of Interval Colorectal Cancer: A Canadian Retrospective Population-Level Analysis from Newfoundland and Labrador

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